C
Christophe M. L. Vande Velde
Researcher at University of Antwerp
Publications - 78
Citations - 1007
Christophe M. L. Vande Velde is an academic researcher from University of Antwerp. The author has contributed to research in topics: Crystal structure & Moiety. The author has an hindex of 17, co-authored 75 publications receiving 820 citations. Previous affiliations of Christophe M. L. Vande Velde include Université libre de Bruxelles & Youngstown State University.
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Journal ArticleDOI
Symmetrical and Nonsymmetrical Chromophores with Tröger’s Base Skeleton: Chiroptical, Linear, and Quadratic Nonlinear Optical Properties—A Joint Theoretical and Experimental Study
Sergey Sergeyev,Sergey Sergeyev,Delphine Didier,Vitaly Boitsov,Ayele Teshome,Inge Asselberghs,Koen Clays,Christophe M. L. Vande Velde,Aurélie Plaquet,Benoît Champagne +9 more
TL;DR: The joint theoretical and experimental studies of chromophores derived from Tröger's base skeleton, in comparison with benchmarkchromophores featuring a dimethylamino group as the donor, provided insight into the relationship between the structure of the new Chromophores and their NLO properties.
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Removal of the pyridine directing group from α-substituted N-(pyridin-2-yl)piperidines obtained via directed Ru-catalyzed sp3 C-H functionalization.
Veerle Smout,Aldo Peschiulli,Stefan Verbeeck,Emily A. Mitchell,Wouter A. Herrebout,Patrick Bultinck,Christophe M. L. Vande Velde,Didier Berthelot,Lieven Meerpoel,Bert U. W. Maes +9 more
TL;DR: Two strategies, "hydrogenation-hydride reduction" and "quaternization-Hydride reduction", are reported that make use of mild reaction conditions (room temperature) to efficiently remove the N-pyridin-2-yl directing group from a diverse set of C- 2-substituted piperidines that were synthesized through directed Ru-catalyzed sp(3) C-H functionalization.
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Synthesis of polycyclic spiroindolines by highly diastereoselective interrupted Ugi cascade reactions of 3-(2-isocyanoethyl)indoles.
Jordy M. Saya,Barry Oppelaar,Răzvan C. Cioc,Gydo van der Heijden,Christophe M. L. Vande Velde,Romano V. A. Orru,Eelco Ruijter +6 more
TL;DR: A highly diastereoselective interrupted Ugi reaction is reported to construct a broad range of structurally congested and stereochemically complex spiroindolines from tryptamine-derived isocyanides to give polycyclic products in moderate to excellent yields.
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Functionalized analogues of Tröger's base: scope and limitations of a general synthetic procedure and facile, predictable method for the separation of enantiomers
Delphine Didier,Benoît Tylleman,Natacha Lambert,Christophe M. L. Vande Velde,Frank Blockhuys,Alain Collas,Sergey Sergeyev +6 more
TL;DR: In this paper, a facile method for the enantioseparation of functionalized Troger's base analogues possessing various substitution patterns was developed, and a detailed report on the scope and limitations of the general synthetic protocol employing anilines and paraformaldehyde in CF3COOH was provided.
Journal ArticleDOI
Iodospirocyclization of Tryptamine-Derived Isocyanides: Formal Total Synthesis of Aspidofractinine.
Jordy M. Saya,Thomas R. Roose,Jarryt J. Peek,Bram Weijers,Thomas J. S. de Waal,Christophe M. L. Vande Velde,Romano V. A. Orru,Eelco Ruijter +7 more
TL;DR: The N-iodosuccinimide-mediated spirocyclization of tryptamine-derived isocyanides to generate spiroindolenines is reported and the synthetic potential was showcased in the formal total synthesis of (±)-aspidofractinine.