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Christopher A. Lavender
Researcher at National Institutes of Health
Publications - 24
Citations - 2837
Christopher A. Lavender is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Gene & Nucleic acid structure. The author has an hindex of 14, co-authored 24 publications receiving 2105 citations. Previous affiliations of Christopher A. Lavender include University of North Carolina at Chapel Hill & University of Tennessee.
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Journal ArticleDOI
Opportunities and obstacles for deep learning in biology and medicine.
Travers Ching,Daniel Himmelstein,Brett K. Beaulieu-Jones,Alexandr A. Kalinin,Brian T. Do,Gregory P. Way,Enrico Ferrero,Paul-Michael Agapow,Michael Zietz,Michael M. Hoffman,Michael M. Hoffman,Wei Xie,Gail L. Rosen,Benjamin J. Lengerich,Johnny Israeli,Jack Lanchantin,Stephen Woloszynek,Anne E. Carpenter,Avanti Shrikumar,Jinbo Xu,Evan M. Cofer,Evan M. Cofer,Christopher A. Lavender,Srinivas C. Turaga,Amr Alexandari,Zhiyong Lu,David J. Harris,Dave DeCaprio,Yanjun Qi,Anshul Kundaje,Yifan Peng,Laura K. Wiley,Marwin H. S. Segler,Simina M. Boca,S. Joshua Swamidass,Austin Huang,Anthony Gitter,Anthony Gitter,Casey S. Greene +38 more
TL;DR: It is found that deep learning has yet to revolutionize biomedicine or definitively resolve any of the most pressing challenges in the field, but promising advances have been made on the prior state of the art.
Journal ArticleDOI
Widespread transcriptional pausing and elongation control at enhancers
Telmo Henriques,Telmo Henriques,Benjamin S. Scruggs,Michiko O. Inouye,Michiko O. Inouye,Ginger W. Muse,Lucy H. Williams,Adam B. Burkholder,Christopher A. Lavender,David C. Fargo,Karen Adelman,Karen Adelman +11 more
TL;DR: It is demonstrated that transcription is a nearly universal feature of enhancers in Drosophila and mammalian cells and that nascent RNA sequencing strategies are optimal for identification of both enhancers and superenhancers.
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RNA-Puzzles: A CASP-like evaluation of RNA three-dimensional structure prediction
José Almeida Cruz,Marc Frédérick Blanchet,Michal J. Boniecki,Janusz M. Bujnicki,Janusz M. Bujnicki,Shi-Jie Chen,Song Cao,Rhiju Das,Feng Ding,Nikolay V. Dokholyan,Samuel C. Flores,Lili Huang,Christopher A. Lavender,Véronique Lisi,François Major,Katarzyna Mikolajczak,Dinshaw J. Patel,Anna Philips,Anna Philips,Tomasz Puton,John SantaLucia,Fredrick Sijenyi,Thomas Hermann,Kristian Rother,Magdalena Rother,Alexander Serganov,Marcin Skorupski,Tomasz Sołtysiński,Parin Sripakdeevong,Irina Tuszynska,Kevin M. Weeks,Christina Waldsich,Michael Wildauer,Neocles B. Leontis,Eric Westhof +34 more
TL;DR: A first, collective, blind experiment in RNA three-dimensional (3D) structure prediction, encompassing three prediction puzzles, to assess the leading edge of RNA structure prediction techniques; compare existing methods and tools; and evaluate their relative strengths, weaknesses, and limitations.
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Multiple Micellization and Dissociation Transitions of Thermo- and Light-Sensitive Poly(ethylene oxide)-b-poly(ethoxytri(ethylene glycol) acrylate-co-o-nitrobenzyl acrylate) in Water
TL;DR: In this article, the synthesis of thermo- and light-sensitive hydrophilic block copolymers, poly(ethylene oxide)-b-poly(ethoxytri(methylene glycol) acrylate-co-o-nitrobenzyl acrylated), and the study of their micellization/dissociation transitions in water in response to temperature changes and UV irradiation were reported.
Journal ArticleDOI
Single-molecule correlated chemical probing of RNA
Philip Homan,Oleg V. Favorov,Christopher A. Lavender,Olcay Kursun,Xiyuan Ge,Steven Busan,Nikolay V. Dokholyan,Kevin M. Weeks +7 more
TL;DR: A simple, experimentally concise, and accurate approach for examining higher-order RNA structure by converting widely used massively parallel sequencing into an easily implemented single-molecule experiment for detecting through-space interactions and multiple conformations.