C
Christopher A. Mitchell
Researcher at Ulster University
Publications - 76
Citations - 5472
Christopher A. Mitchell is an academic researcher from Ulster University. The author has contributed to research in topics: Skeletal muscle & Angiogenesis. The author has an hindex of 31, co-authored 71 publications receiving 4912 citations. Previous affiliations of Christopher A. Mitchell include Max Planck Society & University of Nottingham.
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Journal ArticleDOI
VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia
Holger Gerhardt,Matthew Golding,Marcus Fruttiger,Christiana Ruhrberg,Andrea Lundkvist,Alexandra Abramsson,Michael Jeltsch,Christopher A. Mitchell,Kari Alitalo,David T. Shima,Christer Betsholtz +10 more
TL;DR: It is shown here that VEGF-A controls angiogenic sprouting in the early postnatal retina by guiding filopodial extension from specialized endothelial cells situated at the tips of the vascular sprouts.
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Stereological investigation of placental morphology in pregnancies complicated by pre-eclampsia with and without intrauterine growth restriction.
Terry M. Mayhew,C Ohadike,Philip N. Baker,I.P. Crocker,Christopher A. Mitchell,Stephen S. Ong +5 more
TL;DR: It is concluded that intrauterine growth restriction, but not pre-eclampsia, is associated with substantial changes in placental morphology including impoverished growth of villi and fetal vasculature, likely to reduce placental oxygen diffusive conductances and contribute to fetal hypoxic stress.
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Regulation of endothelial monocyte-activating polypeptide II release by apoptosis
Ulrike E. Knies,Heike A. Behrensdorf,Christopher A. Mitchell,Urban Deutsch,Werner Risau,Hannes C.A. Drexler,Matthias Clauss +6 more
TL;DR: It is shown that, in the mouse embryo, EMAP II mRNA was most abundant at sites of tissue remodeling where many apoptotic cells could be detected by terminal deoxynucleotidyltransferase-mediated dUTP end labeling.
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Preconditioned 70S30C bioactive glass foams promote osteogenesis in vivo.
Swati Midha,Taek Bo Kim,Wouter van den Bergh,Peter D. Lee,Julian R. Jones,Christopher A. Mitchell +5 more
TL;DR: Bioactive glass scaffolds can act as scaffolds for in vivo bone regeneration in a rat tibial defect model, but only when preconditioned, and compositions should be redesigned if sol-gel scaffolds are to be used without preconditionsing to avoid excess calcium release.
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Regression of vessels in the tunica vasculosa lentis is initiated by coordinated endothelial apoptosis: a role for vascular endothelial growth factor as a survival factor for endothelium.
TL;DR: It is shown that widespread apoptosis of the endothelial cells that constitute the tunica vasculosa lentis is occurring already at embryonic day 17.5 of mouse development, much earlier than was reported previously.