C
Christopher A. Voigt
Researcher at Massachusetts Institute of Technology
Publications - 253
Citations - 21291
Christopher A. Voigt is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Racism & Synthetic biology. The author has an hindex of 64, co-authored 242 publications receiving 18053 citations. Previous affiliations of Christopher A. Voigt include California Institute of Technology & University of California.
Papers
More filters
Journal ArticleDOI
Automated design of synthetic ribosome binding sites to control protein expression
TL;DR: A predictive method for designing synthetic ribosome binding sites is developed, enabling a rational control over the protein expression level, and is demonstrated by rationally optimizing protein expression to connect a genetic sensor to a synthetic circuit.
Journal ArticleDOI
Spatiotemporal control of cell signalling using a light-switchable protein interaction
TL;DR: It is shown that light-gated translocation of the upstream activators of Rho-family GTPases, which control the actin cytoskeleton, can be used to precisely reshape and direct the cell morphology of mammalian cells.
Journal ArticleDOI
Genetic circuit design automation
Alec A. K. Nielsen,Bryan S. Der,Bryan S. Der,Jonghyeon Shin,Prashant Vaidyanathan,Vanya Paralanov,Elizabeth A. Strychalski,David J. Ross,Douglas Densmore,Christopher A. Voigt +9 more
TL;DR: Electronic design automation principles from EDA are applied to enable increased circuit complexity and to simplify the incorporation of synthetic gene regulation into genetic engineering projects, and it is demonstrated that engineering principles can be applied to identify and suppress errors that complicate the compositions of larger systems.
Journal ArticleDOI
Robust multicellular computing using genetically encoded NOR gates and chemical ‘wires’
TL;DR: This work helps elucidate the design rules by which simple logic can be harnessed to produce diverse and complex calculations by rewiring communication between cells.
Journal ArticleDOI
Principles of genetic circuit design
TL;DR: In this article, a review describes new tools that aid the construction of genetic circuits and discusses the failure modes encountered when assembling circuits, quantify their impact on performance, and review mitigation efforts.