C
Christopher E.M. Griffiths
Researcher at Manchester Academic Health Science Centre
Publications - 740
Citations - 54154
Christopher E.M. Griffiths is an academic researcher from Manchester Academic Health Science Centre. The author has contributed to research in topics: Psoriasis & Medicine. The author has an hindex of 108, co-authored 671 publications receiving 47675 citations. Previous affiliations of Christopher E.M. Griffiths include Saint Louis University Hospital & French Institute of Health and Medical Research.
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Journal ArticleDOI
Global Epidemiology of Psoriasis: A Systematic Review of Incidence and Prevalence
TL;DR: The data indicated that the occurrence of psoriasis varied according to age and geographic region, being more frequent in countries more distant from the equator and trends in incidence over time.
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Pathogenesis and clinical features of psoriasis.
TL;DR: Comorbidities of psoriasis are attracting interest, and include impairment of quality of life and associated depressive illness, cardiovascular disease, and a seronegative arthritis known as psoriatic arthritis.
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Secukinumab in plaque psoriasis--results of two phase 3 trials.
Richard G. Langley,Boni E. Elewski,Mark Lebwohl,Kristian Reich,Christopher E.M. Griffiths,Kim A. Papp,Lluís Puig,Hidemi Nakagawa,Lynda Spelman,Bárður Sigurgeirsson,Enrique Rivas,Tsen-Fang Tsai,Norman Wasel,Stephen K. Tyring,Thomas Salko,Isabelle Hampele,Marianne Notter,Alexander Karpov,Silvia Helou,Charis Papavassilis +19 more
TL;DR: Secukinumab was effective for psoriasis in two randomized trials, validating interleukin-17A as a therapeutic target and the rates of infection were higher with secuk inumab than with placebo in both studies and were similar to those with etanercept.
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British guideline on the management of asthma: A national clinical guideline
Graham Douglas,Bernard Higgins,Neil Barnes,Anne Boyter,Sherwood Burge,Christopher J Cates,Gary Connett,Jon Couriel,Paul Cullinan,Sheila Edwards,Erica Evans,Monica Fletcher,Christopher E.M. Griffiths,Liam Heaney,Michele Hilton Boon,Steve Holmes,Ruth McArthur,C Nelson-Piercy,Martyn R Partridge,James Y. Paton,Ian D. Pavord,Elaine Carnegie,Hilary Pinnock,Safia Qureshi,Colin F. Robertson,Michael D. Shields,John O. Warner,John H. White +27 more
TL;DR: These guidelines have been replaced by British Guideline on the Management of Asthma.
Journal ArticleDOI
Infliximab induction and maintenance therapy for moderate-to-severe psoriasis : a phase III, multicentre, double-blind trial
Kristian Reich,Frank O. Nestle,Kim A. Papp,Jean-Paul Ortonne,Robert Evans,Cynthia Guzzo,Shu Li,Lisa T. Dooley,Christopher E.M. Griffiths +8 more
TL;DR: Infliximab is effective in both an induction and maintenance regimen for the treatment of moderate-to-severe psoriasis, with a high percentage of patients achieving sustained PASI 75 and PASi 90 improvement through 1 year.