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Christopher Heeschen
Researcher at Shanghai Jiao Tong University
Publications - 183
Citations - 27425
Christopher Heeschen is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: Pancreatic cancer & Stem cell. The author has an hindex of 71, co-authored 172 publications receiving 25743 citations. Previous affiliations of Christopher Heeschen include Queen Mary University of London & Ludwig Maximilian University of Munich.
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Journal ArticleDOI
Distinct Populations of Cancer Stem Cells Determine Tumor Growth and Metastatic Activity in Human Pancreatic Cancer
Patrick C. Hermann,Stephan Huber,Tanja Herrler,Alexandra Aicher,Joachim W. Ellwart,Markus Guba,Christiane J. Bruns,Christopher Heeschen +7 more
TL;DR: It is demonstrated that a subpopulation of migrating CD133(+) CX CR4(+) cancer stem cells is essential for tumor metastasis and strategies aimed at modulating the SDF-1/CXCR4 axis may have important clinical applications to inhibit metastasis of cancer stem Cells.
Journal ArticleDOI
Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells.
Alexandra Aicher,Christopher Heeschen,Christiane Mildner-Rihm,Carmen Urbich,Christian Ihling,Katja Technau-Ihling,Andreas M. Zeiher,S Dimmeler +7 more
TL;DR: It is indicated that eNOS expressed by bone marrow stromal cells influences recruitment of stem and progenitor cells, which may contribute to impaired regeneration processes in ischemic heart disease patients, who are characterized by a reduced systemic NO bioactivity.
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Emergency Room Triage of Patients with Acute Chest Pain by Means of Rapid Testing for Cardiac Troponin T or Troponin I
Christian W. Hamm,Britta U. Goldmann,Christopher Heeschen,Georg Kreymann,Jürgen Berger,Thomas Meinertz +5 more
TL;DR: Bedside tests for cardiac-specific troponins are highly sensitive for the early detection of myocardial-cell injury in acute coronary syndromes and allow rapid and safe discharge of patients with an episode of acute chest pain from the emergency room.
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Myeloperoxidase Serum Levels Predict Risk in Patients With Acute Coronary Syndromes
Stephan Baldus,Christopher Heeschen,Thomas Meinertz,Andreas M. Zeiher,Jason P. Eiserich,Thomas Münzel,Maarten L. Simoons,Christian W. Hamm +7 more
TL;DR: Given its proinflammatory properties, MPO may serve as both a marker and mediator of vascular inflammation and further points toward the significance of PMN activation in the pathophysiology of ACS.
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Improvement of Postnatal Neovascularization by Human Adipose Tissue-Derived Stem Cells
Alexandra Miranville,Christopher Heeschen,Coralie Sengenès,Cyrile Anne Curat,Rudi Busse,Anne Bouloumié +5 more
TL;DR: The data indicate the presence of a cell population within the SVF of human AT characterized as CD34+/CD31− exhibiting characteristics of endothelial progenitor cells, therefore, human AT might represent a source of stem/progenitor cells useful for cell therapy to improve vasculogenesis in adults.