Author
Christopher J. Soares
Bio: Christopher J. Soares is an academic researcher from University of California, Davis. The author has contributed to research in topics: Claisen rearrangement & Hydrogen–deuterium exchange. The author has an hindex of 2, co-authored 3 publications receiving 30 citations.
Papers
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TL;DR: Synthetic confirmation of the C(1′)-(S)-configuration of (+)-dihydropallescensin-2 (1) is reported, the key reaction being a chiron-mediated asymmetric aza-Claisen rearrangement (6→7) as mentioned in this paper.
28 citations
TL;DR: Synthetic confirmation of the C(1′)-(S)-configuration of (+)-dihydropallescensin-2 (1) is reported, the key reaction being a chiron-mediated asymmetric aza-Claisen rearrangement (6→7) as discussed by the authors.
Abstract: Synthetic confirmation of the C(1′)-(S)-configuration of (+)-dihydropallescensin-2 (1) is reported, the key reaction being a chiron-mediated asymmetric aza-Claisen rearrangement (6→7).
2 citations
TL;DR: Advantages of 2-dimethylaminopyridine as base in isotope exchange reactions that occur via enol formation are described for the preparation of deuterium and tritium labeled hexanal.
Abstract: Advantages of 2-dimethylaminopyridine as base in isotope exchange reactions that occur via enol formation are described for the preparation of deuterium and tritium labeled hexanal.
1 citations
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1,378 citations
753 citations
TL;DR: The use of chiral oxazolines as ligands in asymmetric catalysis has been extensively studied in the literature as mentioned in this paper, with a large number of important publications detailing oxazoline-related chemistry, suggesting that research in this area, as in synthetic organic chemistry in general, has yet to mature.
492 citations
TL;DR: In this article, the authors provide an overview of approximately 300 secondary metabolites with inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), which were isolated from various natural sources or derived from synthetic process in the last decades.
Abstract: This article provides an overview of approximately 300 secondary metabolites with inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), which were isolated from various natural sources or derived from synthetic process in the last decades. The structure-activity relationship and the selectivity of some compounds against other protein phosphatases were also discussed. Potential pharmaceutical applications of several PTP1B inhibitors were presented.
173 citations
01 Jan 2012
TL;DR: This article provides an overview of approximately 300 secondary metabolites with inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), which were isolated from various natural sources or derived from synthetic process in the last decades.
Abstract: 这篇文章对蛋白质酷氨酸磷酸酶 1B (PTP1B ) 向约 300 第二等的代谢物的概述提供禁止的活动，它从各种各样的生来的来源被孤立或在最后十年源于合成过程。结构活动关系和对另外的蛋白质磷酸酶的一些混合物的选择也被讨论。几个 PTP1B 禁止者的潜在的药品的应用被介绍。
139 citations