C
Christopher M. Wright
Researcher at University of Pennsylvania
Publications - 27
Citations - 5566
Christopher M. Wright is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 9, co-authored 18 publications receiving 5253 citations. Previous affiliations of Christopher M. Wright include Merck & Co..
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Journal ArticleDOI
The hormone resistin links obesity to diabetes
Claire M. Steppan,Shannon T. Bailey,Savitha Bhat,Elizabeth J. Brown,Ronadip R. Banerjee,Christopher M. Wright,Hiralben R. Patel,Rexford S. Ahima,Mitchell A. Lazar +8 more
TL;DR: It is shown that adipocytes secrete a unique signalling molecule, which is named resistin (for resistance to insulin), which circulating resistin levels are decreased by the anti-diabetic drug rosiglitazone, and increased in diet-induced and genetic forms of obesity.
Journal ArticleDOI
A family of tissue-specific resistin-like molecules
Claire M. Steppan,Elizabeth J. Brown,Christopher M. Wright,Savitha Bhat,Ronadip R. Banerjee,Charlotte Y. Dai,Gregory H. Enders,Debra G. Silberg,Xiaoming Wen,Gary D. Wu,Mitchell A. Lazar +10 more
TL;DR: The RELMs together with resistin comprise a class of tissue-specific signaling molecules that share a cysteine composition and other signature features and suggest a role in intestinal proliferation.
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Diurnal variation of the human adipose transcriptome and the link to metabolic disease
Andrey Loboda,Walter K. Kraft,Bernard Fine,Jeffrey I. Joseph,Michael Nebozhyn,Chunsheng Zhang,Yudong He,Xia Yang,Christopher M. Wright,Mark Morris,Ira Chalikonda,Mark D. Ferguson,Valur Emilsson,Amy Leonardson,John Lamb,Hongyue Dai,Eric E. Schadt,Howard E. Greenberg,Pek Yee Lum +18 more
TL;DR: Diurnal rhythm plays an important role in the physiology and regulation of energy metabolism in the adipose tissue and should be considered in the selection of novel targets for the treatment of obesity and other metabolic disorders.
Journal ArticleDOI
Mito-protective autophagy is impaired in erythroid cells of aged mtDNA-mutator mice.
Xiujie Li-Harms,Sandra Milasta,John P. Lynch,Christopher M. Wright,Aashish Joshi,Rekha Iyengar,Geoffrey Neale,Xi Wang,Yong-Dong Wang,Tomas A. Prolla,James E. Thompson,Joseph T. Opferman,Douglas R. Green,John D. Schuetz,Mondira Kundu +14 more
TL;DR: Findings highlight a pathological feedback loop that explains how dysfunctional mitochondria can escape autophagy-mediated degradation and propagate in cells predisposed to somatic mtDNA mutations, leading to disease.
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Bridging Radiation Therapy Before Commercial Chimeric Antigen Receptor T-Cell Therapy for Relapsed or Refractory Aggressive B-Cell Lymphoma
Christopher M. Wright,Michael J. LaRiviere,Jonathan Baron,C.Z. Uche,Ying Xiao,W. Tristram Arscott,Emily J. Anstadt,Andrew R. Barsky,David Miller,Meredith I. LaRose,Daniel J. Landsburg,Jakub Svoboda,Sunita D. Nasta,James N. Gerson,Stefan K. Barta,Elise A. Chong,Stephen J. Schuster,Ima Paydar,Amit Maity,John P. Plastaras +19 more
TL;DR: Bridging-RT prior to commercial CART does not appear to increase risk for CART-related toxicities or negatively impact outcomes in r/rABL patients, and a trend towards an association for CRS with MTV is seen, however, larger patient numbers are required to elucidate significant associations.