C
Christopher P. Crum
Researcher at Brigham and Women's Hospital
Publications - 417
Citations - 35369
Christopher P. Crum is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Serous fluid & Cervical intraepithelial neoplasia. The author has an hindex of 87, co-authored 412 publications receiving 32399 citations. Previous affiliations of Christopher P. Crum include Boston Children's Hospital & University of Michigan.
Papers
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Journal ArticleDOI
p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development
Annie Yang,Ronen Schweitzer,Deqin Sun,Mourad Kaghad,Nancy Walker,Roderick T. Bronson,Clifford J. Tabin,Arlene H. Sharpe,Daniel Caput,Christopher P. Crum,Frank McKeon +10 more
TL;DR: It is reported that mice homozygous for a disrupted p63 gene have major defects in their limb, craniofacial and epithelial development, and results indicate that p63 is critical for maintaining the progenitor-cell populations that are necessary to sustain epithelialDevelopment and morphogenesis.
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Intraepithelial carcinoma of the fimbria and pelvic serous carcinoma: Evidence for a causal relationship.
David Kindelberger,Yonghee Lee,Alexander Miron,Michelle S. Hirsch,Colleen M. Feltmate,Fabiola Medeiros,Michael J. Callahan,Elizabeth I.O. Garner,Robert W. Gordon,Chandler Birch,Ross S. Berkowitz,Michael G. Muto,Christopher P. Crum +12 more
TL;DR: TIC coexists with all forms of pelvic serous carcinoma and is a plausible origin for many of these tumors, although further studies are needed to elucidate the etiologic significance.
Journal ArticleDOI
The tubal fimbria is a preferred site for early adenocarcinoma in women with familial ovarian cancer syndrome.
Fabiola Medeiros,Michael G. Muto,Yonghee Lee,Julia A. Elvin,Michael J. Callahan,Colleen M. Feltmate,Judy Garber,Daniel W. Cramer,Christopher P. Crum +8 more
TL;DR: The fimbria was the most common location for early serous carcinoma in this series of BRCA-positive women, and Investigative strategies targeting the fimbriated end of the fallopian tube should further define its role in the pathogenesis of familial and sporadic ovarianSerous carcinomas.
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A candidate precursor to serous carcinoma that originates in the distal fallopian tube.
Yonghee Lee,A. Miron,Ronny Drapkin,Marisa R. Nucci,Fabiola Medeiros,Aasia Saleemuddin,Judy Garber,C Birch,Hongmei Mou,R W Gordon,Daniel W. Cramer,Frank McKeon,Christopher P. Crum +12 more
TL;DR: The p53 signature and its malignant counterpart (TIC) underline the significance of the fimbria, both as a candidate site for serous carcinogenesis and as a target for future research on the early detection and prevention of this disease.
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p63 Is Essential for the Proliferative Potential of Stem Cells in Stratified Epithelia
TL;DR: P63, a gene whose deletion in mice results in the catastrophic loss of all stratified epithelia, is analyzed and it is demonstrated that p63 is strongly expressed in epithelial cells with high clonogenic and proliferative capacity and that stem cells lacking p63 undergo a premature proliferative rundown.