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Christopher Pittenger

Researcher at Yale University

Publications -  185
Citations -  15612

Christopher Pittenger is an academic researcher from Yale University. The author has contributed to research in topics: Medicine & Tourette syndrome. The author has an hindex of 54, co-authored 157 publications receiving 13194 citations. Previous affiliations of Christopher Pittenger include Kyoto Prefectural University of Medicine & Columbia University.

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Stress, Depression, and Neuroplasticity: A Convergence of Mechanisms

TL;DR: Greater appreciation of the convergence of mechanisms between stress, depression, and neuroplasticity is likely to lead to the identification of novel targets for more efficacious treatments.
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Analysis of shared heritability in common disorders of the brain

Verneri Anttila, +720 more
- 22 Jun 2018 - 
TL;DR: It is demonstrated that, in the general population, the personality trait neuroticism is significantly correlated with almost every psychiatric disorder and migraine, and it is shown that both psychiatric and neurological disorders have robust correlations with cognitive and personality measures.
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Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders

Phil Lee, +606 more
- 12 Dec 2019 - 
TL;DR: Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci within genes that show heightened expression in the brain throughout the lifespan, beginning prenatally in the second trimester, and play prominent roles in neurodevelopmental processes.
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Meta-analysis of the symptom structure of obsessive-compulsive disorder.

TL;DR: A four-factor structure explained a large proportion of the heterogeneity in the clinical symptoms of OCD and further item-level factor analyses are needed to determine the appropriate placement of miscellaneous somatic and checking OCD symptoms.
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Reversible Inhibition of CREB/ATF Transcription Factors in Region CA1 of the Dorsal Hippocampus Disrupts Hippocampus-Dependent Spatial Memory

TL;DR: These experiments represent the first targeting of the dorsal hippocampus in genetically modified mice and confirm a role for CREB in hippocampus-dependent learning and suggest that some experimental forms of plasticity bypass the requirement forCREB.