C
Christopher T. Jones
Researcher at Rockefeller University
Publications - 21
Citations - 4890
Christopher T. Jones is an academic researcher from Rockefeller University. The author has contributed to research in topics: Virus & Hepatitis C virus. The author has an hindex of 16, co-authored 21 publications receiving 4510 citations.
Papers
More filters
Journal ArticleDOI
A diverse range of gene products are effectors of the type I interferon antiviral response
John W. Schoggins,Sam J. Wilson,Maryline Panis,Mary Murphy,Christopher T. Jones,Paul D. Bieniasz,Charles M. Rice +6 more
TL;DR: It is shown that different viruses are targeted by unique sets of ISGs, and that each viral species is susceptible to multiple antiviral genes, which together encompass a range of inhibitory activities.
Journal ArticleDOI
Hepatitis C Virus p7 and NS2 Proteins Are Essential for Production of Infectious Virus
TL;DR: It is concluded that p7 and NS2 function at an early stage of virion morphogenesis, prior to the assembly of infectious virus.
Journal ArticleDOI
Time- and Temperature-Dependent Activation of Hepatitis C Virus for Low-pH-Triggered Entry
Donna M. Tscherne,Christopher T. Jones,Matthew J. Evans,Brett D. Lindenbach,Jane A. McKeating,Charles M. Rice +5 more
TL;DR: There are rate-limiting, postbinding events that are needed to render HCV competent for low-pH-triggered entry, and these events may involve interaction with a cellular coreceptor or other factors but do not require cathepsins B and L, late endosomal proteases that activate Ebola virus and reovirus for entry.
Journal ArticleDOI
A genetically humanized mouse model for hepatitis C virus infection
Marcus Dorner,Joshua A. Horwitz,Justin B. Robbins,Walter T. Barry,Qian Feng,Kathy Mu,Christopher T. Jones,John W. Schoggins,Maria Teresa Catanese,Dennis R. Burton,Dennis R. Burton,Mansun Law,Charles M. Rice,Alexander Ploss +13 more
TL;DR: It is demonstrated that HCV can be blocked by passive immunization, as well as showing that a recombinant vaccinia virus vector induces humoral immunity and confers partial protection against heterologous challenge.
Journal ArticleDOI
Cell culture–produced hepatitis C virus does not infect peripheral blood mononuclear cells
Svetlana Marukian,Christopher T. Jones,Linda Andrus,Matthew J. Evans,Kimberly D. Ritola,Edgar D. Charles,Charles M. Rice,Lynn B. Dustin +7 more
TL;DR: It is concluded that multiple blocks prevent blood cells from supporting HCV infection and is bypassed by transfecting HCV RNA into blood cell subsets.