C
Christopher W. V. Hogue
Researcher at University of Toronto
Publications - 56
Citations - 17557
Christopher W. V. Hogue is an academic researcher from University of Toronto. The author has contributed to research in topics: Interaction network & Protein structure. The author has an hindex of 30, co-authored 56 publications receiving 16231 citations. Previous affiliations of Christopher W. V. Hogue include Mount Sinai Hospital & University of Washington.
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Journal ArticleDOI
An automated method for finding molecular complexes in large protein interaction networks.
TL;DR: A novel graph theoretic clustering algorithm, "Molecular Complex Detection" (MCODE), that detects densely connected regions in large protein-protein interaction networks that may represent molecular complexes is described.
Journal ArticleDOI
Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry
Yuen Ho,Albrecht Gruhler,Adrian Heilbut,Gary D. Bader,Gary D. Bader,Lynda Moore,Sally-Lin Adams,Anna Millar,Paul J. Taylor,Keiryn L. Bennett,Kelly Boutilier,Lingyun Yang,Cheryl Wolting,Ian Donaldson,Søren Schandorff,Juanita Shewnarane,Mai Vo,Joanne Taggart,Marilyn Goudreault,Brenda Muskat,Cris Alfarano,Danielle Dewar,Zhen Lin,Katerina Michalickova,Katerina Michalickova,Andrew Willems,Andrew Willems,Holly Sassi,Peter A Nielsen,Karina Juhl Rasmussen,Jens R. Andersen,Lene E. Johansen,Lykke Haastrup Hansen,Hans Jespersen,Alexandre V. Podtelejnikov,Eva Nielsen,Janne S. Crawford,Vibeke Poulsen,Birgitte D Sørensen,Jesper Matthiesen,Ronald C. Hendrickson,Frank Gleeson,Tony Pawson,Tony Pawson,Michael Moran,Daniel Durocher,Daniel Durocher,Matthias Mann,Christopher W. V. Hogue,Christopher W. V. Hogue,Daniel Figeys,Mike Tyers,Mike Tyers +52 more
TL;DR: Comparison of the HMS-PCI data set with interactions reported in the literature revealed an average threefold higher success rate in detection of known complexes compared with large-scale two-hybrid studies.
Journal ArticleDOI
Systematic Genetic Analysis with Ordered Arrays of Yeast Deletion Mutants
Amy Hin Yan Tong,Marie Evangelista,Ainslie B. Parsons,Hong Xu,Gary D. Bader,Gary D. Bader,Nicholas Pagé,Mark D. Robinson,Sasan Raghibizadeh,Christopher W. V. Hogue,Christopher W. V. Hogue,Howard Bussey,Brenda J. Andrews,Mike Tyers,Mike Tyers,Charles Boone,Charles Boone +16 more
TL;DR: A method for systematic construction of double mutants, termed synthetic genetic array (SGA) analysis, in which a query mutation is crossed to an array of ∼4700 deletion mutants is developed, which should produce a global map of gene function.
Journal ArticleDOI
BIND: the Biomolecular Interaction Network Database
TL;DR: The BIND anticipates the coming large influx of interaction information from high-throughput proteomics efforts including detailed information about post-translational modifications from mass spectrometry.
Journal ArticleDOI
A Combined Experimental and Computational Strategy to Define Protein Interaction Networks for Peptide Recognition Modules
Amy Hin Yan Tong,Becky Drees,Giuliano Nardelli,Gary D. Bader,Barbara Brannetti,Luisa Castagnoli,Marie Evangelista,Silvia Ferracuti,Bryce Nelson,Serena Paoluzi,Michele Quondam,Adriana Zucconi,Christopher W. V. Hogue,Stanley Fields,Charles Boone,Gianni Cesareni +15 more
TL;DR: A strategy combining computational prediction of interactions from phage-display ligand consensus sequences with large-scale two-hybrid physical interaction tests is developed, resulting in a strategy containing 59 highly likely interactions common to both networks.