Chuke Nwachuku

TL;DR: Thiazide-type diuretics are superior in preventing 1 or more major forms of CVD and are less expensive and should be preferred for first-step antihypertensive therapy.

TL;DR: The AllHAT trial as mentioned in this paper is a randomized clinical outcome trial of antihypertensive and lipid-lowering therapy in a diverse population (including substantial numbers of women and minorities) of 42,419 high-risk hypertensives aged > or = 55 years with a planned mean follow-up of 6 years.

TL;DR: The results provide no evidence of superiority for treatment with calcium channel blockers or angiotensin-converting enzyme inhibitors compared with a thiazide-type diuretic during first-step antihypertensive therapy in DM, IFG, or NG.

TL;DR: It was found that coronary heart disease was much more common than end-stage renal disease in hypertensive patients with moderate to severe reductions in GFR who were followed for 6 years, and lower baseline GFR was associated with higher risk for CHD independent of other risk factors.

TL;DR: In hypertensive patients, the risks for coronary events are similar, but for stroke, combined CVD, gastrointestinal bleeding, and angioedema are higher and for heart failure are lower for lisinopril-based compared with amlodipine-based therapy.