Chulwon Kim

Bio: Chulwon Kim is an academic researcher from Kyung Hee University. The author has contributed to research in topics: STAT3 & Tourism. The author has an hindex of 31, co-authored 66 publications receiving 3756 citations. Previous affiliations of Chulwon Kim include Texas A&M University.

Destination competitiveness: determinants and indicators

Abstract: The paper develops a model of destination competitiveness that will enable comparisons between countries and between tourism sector industries. The model seeks to capture the main elements of competitiveness highlighted in the general literature, while appreciating the special issues involved in exploring the notion of destination competitiveness as emphasised by tourism researchers. Associated with the model is a set of indicators that can be used to measure the competitiveness of any given destination. These indicators, comprising both objective and subjective measures, were identified from the major elements comprising the generic destination competitiveness model and also from discussions at workshops held in Korea and Australia. This paper has four major objectives: to develop a model of destination competitiveness that identifies key success factors in determining destination competitiveness; to develop an appropriate set of indicators of destination competitiveness; to highlight the advantages and ...

Attributes of destination competitiveness: a factor analysis

Abstract: A model is developed to capture the main elements of competitiveness highlighted in the general literature, while appreciating the special issues involved in exploring the notion of destination competitiveness as emphasized by tourism researchers. Associated with the model is a set of indicators that can be used to measure the competitiveness of any given destination. These indicators, comprising both objective and subjective measures, were identified from the major elements comprising the generic destination competitiveness model and also from discussions at workshops held in Korea and Australia in 2001. This article has three major objectives: to display a model of destination competitiveness that identifies key success factors in determining destination competitiveness; to display the findings arising from the application of factor analysis to survey data collected in a study of Australian and Korean tourism industry stakeholders; to explore issues for further research arising from the study.

Ginkgolic Acid Inhibits Invasion and Migration and TGF-β-Induced EMT of Lung Cancer Cells Through PI3K/Akt/mTOR Inactivation.

Abstract: Epithelial-to-mesenchymal transition (EMT) is a critical cellular phenomenon regulating tumor metastases. In the present study, we investigated whether ginkgolic acid can affect EMT in lung cancer cells and the related underlying mechanism(s) of its actions. We found that ginkgolic acid C15:1 (GA C15:1) inhibited cell proliferation, invasion, and migration in both A549 and H1299 lung cancer cells. GA C15:1 also suppressed the expression of EMT related genes (Fibronectin, Vimentin, N-cadherin, MMP-9, MMP-2, Twist and Snail) and suppressed TGF-β-induced EMT as assessed by reduced expression of mesenchymal markers (Fibronectin, Vimentin, N-cadherin), MMP-9, MMP-2, Twist and Snail. However, GA C15:1 did not affect the expression of various epithelial marker proteins (Occludin and E-cadherin) in both A549 and H1299 cells. TGF-β-induced morphologic changes from epithelial to mesenchymal cells and induction of invasion and migration were reversed by GA C15:1. Finally, GA C15:1 not only abrogated basal PI3K/Akt/mTOR signaling cascade, but also reduced TGF-β-induced phosphorylation of PI3K/Akt/mTOR pathway in lung cancer cells. Overall, these findings suggest that GA C15:1 suppresses lung cancer invasion and migration through the inhibition of PI3K/Akt/mTOR signaling pathway and provide a source of potential therapeutic compounds to control the metastatic dissemination of tumor cells. J. Cell. Physiol. 232: 346-354, 2017. © 2016 Wiley Periodicals, Inc.

Understanding the Cultural Differences in Tourist Motivation Between Anglo-American and Japanese Tourists

Abstract: Summary There is considerable evidence to suggest that differences in cultural characteristics exist across the world. Among them, individualistic societies emphasize “I” consciousness, autonomy, emotional independence, pleasure seeking and universalism. On the other hand, col-lectivistic societies stress “we” consciousness, collective identity, group solidarity, sharing, and particularism. A comparative research on the motivation of tourists from different cultures may challenge current tourism research, which mainly focuses on individualism and rationalism. These values of individualism and rationalism result in underestimation of the influence of groups, norms, culture, and emotion or impulse on tourist behavior. There have been few studies which attempt to directly measure cultural characteristics and identity across culture, and to explain how these cultural characteristics play a role in creating distinctive differences in tourist motivation. Thus, this study explores (1) cultural differences underl...

Using Multivariate Statistics

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Destination Competitiveness: An Analysis of Determinant Attributes

Abstract: The aim of this study was to develop an insight into the importance and impact of attributes which affect the competitiveness of tourism destinations. Using a general conceptual model of destination competitiveness, 36 competitiveness attributes were evaluated by “expert” judgment in the form of an online survey of destination managers and tourism researchers. These judgments were integrated and analyzed using the analytic hierarchy process (AHP). In addition to estimating the importance of the attributes of competitiveness, the results of the AHP were further analyzed to produce measures of attribute determinance. These measures were then tested statistically to identify which attributes were judged to exert the greatest determinant impact on destination competitiveness. Ten of the 36 attributes were found to have determinance measures statistically significantly greater than average.

Role of Reactive Oxygen Species in Cancer Progression: Molecular Mechanisms and Recent Advancements.

Abstract: Reactive oxygen species (ROS) play a pivotal role in biological processes and continuous ROS production in normal cells is controlled by the appropriate regulation between the silver lining of low and high ROS concentration mediated effects. Interestingly, ROS also dynamically influences the tumor microenvironment and is known to initiate cancer angiogenesis, metastasis, and survival at different concentrations. At moderate concentration, ROS activates the cancer cell survival signaling cascade involving mitogen-activated protein kinase/extracellular signal-regulated protein kinases 1/2 (MAPK/ERK1/2), p38, c-Jun N-terminal kinase (JNK), and phosphoinositide-3-kinase/ protein kinase B (PI3K/Akt), which in turn activate the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), matrix metalloproteinases (MMPs), and vascular endothelial growth factor (VEGF). At high concentrations, ROS can cause cancer cell apoptosis. Hence, it critically depends upon the ROS levels, to either augment tumorigenesis or lead to apoptosis. The major issue is targeting the dual actions of ROS effectively with respect to the concentration bias, which needs to be monitored carefully to impede tumor angiogenesis and metastasis for ROS to serve as potential therapeutic targets exogenously/endogenously. Overall, additional research is required to comprehend the potential of ROS as an effective anti-tumor modality and therapeutic target for treating malignancies.