C
Chun-Hyung Kim
Researcher at Harvard University
Publications - 51
Citations - 3934
Chun-Hyung Kim is an academic researcher from Harvard University. The author has contributed to research in topics: Induced pluripotent stem cell & Norepinephrine transporter. The author has an hindex of 22, co-authored 51 publications receiving 3627 citations. Previous affiliations of Chun-Hyung Kim include Seoul National University & University of Tennessee.
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Journal ArticleDOI
Generation of human induced pluripotent stem cells by direct delivery of reprogramming proteins.
Dohoon Kim,Chun-Hyung Kim,Jung-Il Moon,Young-Gie Chung,Mi-Yoon Chang,Baek-Soo Han,Sanghyeok Ko,Eungi Yang,Kwang Yul Cha,Robert Lanza,Kwang Soo Kim +10 more
TL;DR: Document S1.
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A quantitative-trait analysis of human plasma-dopamine β-hydroxylase activity: Evidence for a major functional polymorphism at the DBH locus
Cyrus P. Zabetian,George M. Anderson,Sarah G. Buxbaum,Robert C. Elston,Hiroshi Ichinose,Toshiharu Nagatsu,Kwang-Soo Kim,Chun-Hyung Kim,Robert T. Malison,Joel Gelernter,Joseph F. Cubells +10 more
TL;DR: It is demonstrated that --1021C-->T is a major genetic marker for plasma-D beta H activity and provide new tools for investigation of the role of both D beta H and the DBH gene in human disease.
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Orphan nuclear receptor Nurr1 directly transactivates the promoter activity of the tyrosine hydroxylase gene in a cell-specific manner.
Kwang-Soo Kim,Chun-Hyung Kim,Dong Youn Hwang,Hyemyung Seo,Sangmi Chung,Seok Jong Hong,Jinkyu Lim,T. Anderson,Ole Isacson +8 more
TL;DR: It is shown that Nurr1, an orphan nuclear receptor critical for dopaminergic neuron development, directly transactivates the promoter activity of the TH gene in a cell type‐dependent manner, while it does not regulate the DBH promoter.
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Wnt1-lmx1a forms a novel autoregulatory loop and controls midbrain dopaminergic differentiation synergistically with the SHH-FoxA2 pathway.
Sangmi Chung,Amanda Leung,Baek Soo Han,Mi Yoon Chang,Jung Il Moon,Chun-Hyung Kim,Sunghoi Hong,Jan Pruszak,Ole Isacson,Kwang-Soo Kim +9 more
TL;DR: Two regulatory loops critically link extrinsic signals to cell-intrinsic factors and cooperatively regulate mDA neuron development and coactivation of both Wnt1 and SHH pathways by exogenous expression of Lmx1a, Otx2, and FoxA2 synergistically enhanced the differentiation of ESCs to mDA neurons.
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A polymorphism in the norepinephrine transporter gene alters promoter activity and is associated with attention-deficit hyperactivity disorder.
Chun-Hyung Kim,Maureen K. Hahn,Yoo-Sook Joung,Susan L. Anderson,A. Steele,Michelle S. Mazei-Robinson,Ian R. Gizer,Martin H. Teicher,Bruce M. Cohen,David Robertson,Irwin D. Waldman,Randy D. Blakely,Kwang-Soo Kim +12 more
TL;DR: A previously uncharacterized and common A/T polymorphism at −3081 upstream of the transcription initiation site of the human norepinephrine transporter gene is reported, suggesting that anomalous transcription factor-based repression of SLC6A2 may increase risk for the development of attention-deficit hyperactivity disorder and other neuropsychiatric diseases.