Chun Lam

TL;DR: Rising circulating levels of soluble endoglin and ratios of sFlt1:PlGF herald the onset of preeclampsia, which was greatest among women in the highest quartile of the control distributions for both biomarkers but not for either biomarker alone.

TL;DR: Testing the hypothesis that urinary PlGF is reduced prior to onset of hypertension and proteinuria and that this reduction predicts preeclampsia found decreased urinary Pl GF at mid gestation is strongly associated with subsequent early development of preeClampsia.

TL;DR: It is suggested that circulating soluble endoglin and spil-which cause endothelial dysfunction by different mechanisms-may contribute to the development of preeclampsia.

TL;DR: Women with a history of preeclampsia demonstrate altered expression of angiogenesis-related proteins and increased HOMA(IR) more than 1 yr postpartum, which may contribute to their risk of future CVD.

TL;DR: Serum levels of the proangiogenic factor PlGF were decreased, and those of the anti- angiogenic ratio sFlt-1/PlGF were increased in nulliparous women who subsequently developed hypertension and placental abruption.