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Chun-Long Chen
Researcher at PSL Research University
Publications - 51
Citations - 4682
Chun-Long Chen is an academic researcher from PSL Research University. The author has contributed to research in topics: Gene & DNA replication. The author has an hindex of 18, co-authored 43 publications receiving 3979 citations. Previous affiliations of Chun-Long Chen include University of Paris-Sud & Centre national de la recherche scientifique.
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Journal ArticleDOI
The Chlamydomonas Genome Reveals the Evolution of Key Animal and Plant Functions
Sabeeha S. Merchant,Simon E. Prochnik,Olivier Vallon,Elizabeth H. Harris,Steven J. Karpowicz,George B. Witman,Astrid Terry,Asaf Salamov,Lillian K. Fritz-Laylin,Laurence Maréchal-Drouard,Wallace F. Marshall,Liang-Hu Qu,David R. Nelson,Anton A. Sanderfoot,Martin H. Spalding,Vladimir V. Kapitonov,Qinghu Ren,Patrick J. Ferris,Erika Lindquist,Harris Shapiro,Susan Lucas,Jane Grimwood,Jeremy Schmutz,Pierre Cardol,Pierre Cardol,Heriberto Cerutti,Guillaume Chanfreau,Chun-Long Chen,Valérie Cognat,Martin T. Croft,Rachel M. Dent,Susan K. Dutcher,Emilio Fernández,Hideya Fukuzawa,David González-Ballester,Diego González-Halphen,Armin Hallmann,Marc Hanikenne,Michael Hippler,William Inwood,Kamel Jabbari,Ming Kalanon,Richard Kuras,Paul A. Lefebvre,Stéphane D. Lemaire,Alexey V. Lobanov,Martin Lohr,Andrea L Manuell,Iris Meier,Laurens Mets,Maria Mittag,Telsa M. Mittelmeier,James V. Moroney,Jeffrey L. Moseley,Carolyn A. Napoli,Aurora M. Nedelcu,Krishna K. Niyogi,Sergey V. Novoselov,Ian T. Paulsen,Greg Pazour,Saul Purton,Jean-Philippe Ral,Diego Mauricio Riaño-Pachón,Wayne R. Riekhof,Linda A. Rymarquis,Michael Schroda,David B. Stern,James G. Umen,Robert D. Willows,Nedra F. Wilson,Sara L. Zimmer,Jens Allmer,Janneke Balk,Katerina Bisova,Chong-Jian Chen,Marek Eliáš,Karla C Gendler,Charles R. Hauser,Mary Rose Lamb,Heidi K. Ledford,Joanne C. Long,Jun Minagawa,M. Dudley Page,Junmin Pan,Wirulda Pootakham,Sanja Roje,Annkatrin Rose,Eric Stahlberg,Aimee M. Terauchi,Pinfen Yang,Steven G. Ball,Chris Bowler,Carol L. Dieckmann,Vadim N. Gladyshev,Pamela J. Green,Richard A. Jorgensen,Stephen P. Mayfield,Bernd Mueller-Roeber,Sathish Rajamani,Richard T. Sayre,Peter Brokstein,Inna Dubchak,David Goodstein,Leila Hornick,Y. Wayne Huang,Jinal Jhaveri,Yigong Luo,Diego Martinez,Wing Chi Abby Ngau,Bobby Otillar,Alexander Poliakov,Aaron Porter,Lukasz Szajkowski,Gregory Werner,Kemin Zhou,Igor V. Grigoriev,Daniel S. Rokhsar,Daniel S. Rokhsar,Arthur R. Grossman +118 more
TL;DR: Analyses of the Chlamydomonas genome advance the understanding of the ancestral eukaryotic cell, reveal previously unknown genes associated with photosynthetic and flagellar functions, and establish links between ciliopathy and the composition and function of flagella.
Journal ArticleDOI
XUTs are a class of Xrn1-sensitive antisense regulatory non-coding RNA in yeast
E. van Dijk,Chun-Long Chen,Yves d'Aubenton-Carafa,Stephanie Gourvennec,Marta Kwapisz,Veronique Roche,Catherine Bertrand,Maud Silvain,Patricia Legoix-Né,Sophie Loeillet,Alain Nicolas,Claude Thermes,Antonin Morillon,Antonin Morillon +13 more
TL;DR: A novel class of 1,658 Xrn1-sensitive unstable transcripts (XUTs) in which 66% are antisense to open reading frames are identified, demonstrating that antisense ncRNA-mediated regulation is a general regulatory pathway for gene expression in S. cerevisiae.
Journal ArticleDOI
Replication landscape of the human genome.
Nataliya Petryk,Malik Kahli,Yves d'Aubenton-Carafa,Yan Jaszczyszyn,Yimin Shen,Maud Silvain,Claude Thermes,Chun-Long Chen,Olivier Hyrien +8 more
TL;DR: This novel panorama of replication reveals how chromatin and transcription modulate the initiation process to create cell-type-specific replication programs.
Journal ArticleDOI
Impact of replication timing on non-CpG and CpG substitution rates in mammalian genomes
Chun-Long Chen,Aurélien Rappailles,Lauranne Duquenne,Maxime Huvet,Guillaume Guilbaud,Laurent Farinelli,Benjamin Audit,Yves d'Aubenton-Carafa,Alain Arneodo,Olivier Hyrien,Claude Thermes +10 more
TL;DR: Results in the mouse indicate that replication timing is a main factor affecting nucleotide substitution dynamics at non-CpG sites and constitutes a major neutral process driving mammalian genome evolution.
Journal ArticleDOI
Evidence for Sequential and Increasing Activation of Replication Origins along Replication Timing Gradients in the Human Genome
Guillaume Guilbaud,Aurélien Rappailles,Antoine Baker,Antoine Baker,Chun-Long Chen,Alain Arneodo,Alain Arneodo,Arach Goldar,Yves d'Aubenton-Carafa,Claude Thermes,Benjamin Audit,Benjamin Audit,Olivier Hyrien +12 more
TL;DR: A quantitative genome-wide analysis of DNA replication kinetics in several human cell types that contradicts the view that mammalian chromosomes consist of megabase-scale domains of coordinated origin firing separated by large originless transition regions and sheds a new light on the replication timing program of mammalian genomes.