C
Chung-Hsuan Chen
Researcher at Academia Sinica
Publications - 174
Citations - 7604
Chung-Hsuan Chen is an academic researcher from Academia Sinica. The author has contributed to research in topics: Mass spectrometry & Ion. The author has an hindex of 43, co-authored 171 publications receiving 6550 citations. Previous affiliations of Chung-Hsuan Chen include National Taiwan University & Nanjing University of Information Science and Technology.
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Journal ArticleDOI
Test environments and mechanical properties of Zr-base bulk amorphous alloys
C.T. Liu,Lee Heatherly Jr,J.A. Horton,D.S. Easton,C. A. Carmichael,J.L. Wright,Joachim H. Schneibel,M. H. Yoo,Chung-Hsuan Chen,Akihisa Inoue +9 more
TL;DR: In this paper, the mechanical properties of two Zr-base bulk amorphous alloys (BAA) were studied by both tensile and compressive tests at room temperature in various test environments and the results suggest that moisture-induced hydrogen embrittlement in BAAs may be masked by catastrophic fracture following shear bands.
Journal ArticleDOI
Deubiquitination and Stabilization of PD-L1 by CSN5
Seung Oe Lim,Chia Wei Li,Weiya Xia,Jong Ho Cha,Li Chuan Chan,Yun Wu,Shih Shin Chang,Shih Shin Chang,Wan Chi Lin,Jung Mao Hsu,Yi Hsin Hsu,Taewan Kim,Wei Chao Chang,Jennifer L. Hsu,Hirohito Yamaguchi,Qingqing Ding,Yan Wang,Yi Yang,Chung-Hsuan Chen,Aysegul A. Sahin,Dihua Yu,Dihua Yu,Gabriel N. Hortobagyi,Mien Chie Hung +23 more
TL;DR: It is demonstrated that COP9 signalosome 5 (CSN5), induced by NF-κB p65, is required for TNF-α-mediated PD-L1 stabilization in cancer cells, and inhibition of CSN5 by curcumin diminished cancer cell PD- L1 expression and sensitized cancer cells to anti-CTLA4 therapy.
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Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1.
Jong Ho Cha,Wen Hao Yang,Weiya Xia,Yongkun Wei,Li Chuan Chan,Seung Oe Lim,Chia Wei Li,Taewan Kim,Shih Shin Chang,Heng Huan Lee,Jennifer L. Hsu,Hung Ling Wang,Chu Wei Kuo,Wei Chao Chang,Sirwan Hadad,Colin A. Purdie,Aaron McCoy,Shirong Cai,Yizheng Tu,Jennifer K. Litton,Elizabeth A. Mittendorf,Stacy L. Moulder,William Fraser Symmans,Alastair M. Thompson,Helen Piwnica-Worms,Chung-Hsuan Chen,Kay-Hooi Khoo,Mien Chie Hung +27 more
TL;DR: It is shown that metformin increases CTL activity by reducing the stability and membrane localization of programmed death ligand-1 (PD-L1), and it is discovered that AMP-activated protein kinase (AMPK) activated by met formin directly phosphorylates S195 of PD-L 1.
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EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2
Jia Shen,Weiya Xia,Yekaterina B. Khotskaya,Longfei Huo,Kotaro Nakanishi,Seung Oe Lim,Yi Du,Yan Wang,Wei Chao Chang,Wei Chao Chang,Chung-Hsuan Chen,Jennifer L. Hsu,Jennifer L. Hsu,Jennifer L. Hsu,Yun Wu,Yung Carmen Lam,Brian P. James,Xiuping Liu,Chang Gong Liu,Dinshaw J. Patel,Mien Chie Hung +20 more
TL;DR: The study reveals a previously unrecognized function of EGFR in miRNA maturation and demonstrates how EGFR is likely to function as a regulator of AGO2 through novel post-translational modification, suggesting that modulation of miRNA biogenesis is important for stress response in tumour cells and has potential clinical implications.
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Sialylation and fucosylation of epidermal growth factor receptor suppress its dimerization and activation in lung cancer cells
Ying-Chih Liu,Hsin-Yung Yen,Chien-Yu Chen,Chein-Hung Chen,Ping-Fu Cheng,Yi-Hsiu Juan,Chung-Hsuan Chen,Kay-Hooi Khoo,Chong-Jen Yu,Pan-Chyr Yang,Tsui-Ling Hsu,Chi-Huey Wong +11 more
TL;DR: Increasing sialylation and fucosylation could attenuate EGFR-mediated invasion of lung cancer cells and incorporation of the core fucose by α1,6-fucOSylatransferase (FUT8) would promote EGFR dimerization and phosphorylation.