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Chunhui Xu
Researcher at Emory University
Publications - 87
Citations - 9162
Chunhui Xu is an academic researcher from Emory University. The author has contributed to research in topics: Induced pluripotent stem cell & Embryonic stem cell. The author has an hindex of 29, co-authored 83 publications receiving 8771 citations. Previous affiliations of Chunhui Xu include The Wallace H. Coulter Department of Biomedical Engineering & Georgia Institute of Technology.
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Journal ArticleDOI
Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts
Michael A. Laflamme,Kent Chen,Anna V. Naumova,Veronica Muskheli,James A. Fugate,Sarah K. Dupras,Hans Reinecke,Chunhui Xu,Mohammad Hassanipour,Chris O'Sullivan,Lila R. Collins,Yinhong Chen,Elina Minami,Edward A. Gill,Shuichi Ueno,Chun Yuan,Joseph K. Gold,Charles E. Murry +17 more
TL;DR: This work generated highly purified human cardiomyocytes using a readily scalable system for directed differentiation that relies on activin A and BMP4, and identified a cocktail of pro-survival factors that limitsCardiomyocyte death after transplantation.
Journal ArticleDOI
Feeder-free growth of undifferentiated human embryonic stem cells.
Chunhui Xu,Margaret S. Inokuma,Jerrod Denham,Kathaleen Golds,Pratima Kundu,Joseph D. Gold,Melissa K. Carpenter +6 more
TL;DR: A successful feeder-free hES culture system in which undifferentiated cells can be maintained for at least 130 population doublings and are suitable for scaleup production is demonstrated.
Journal ArticleDOI
Characterization and Enrichment of Cardiomyocytes Derived From Human Embryonic Stem Cells
TL;DR: The extended replicative capacity of hES cells and the ability to differentiate and enrich for functional human cardiomyocytes warrant further development of these cells for clinical application in heart diseases.
Journal ArticleDOI
Basic Fibroblast Growth Factor Supports Undifferentiated Human Embryonic Stem Cell Growth Without Conditioned Medium
Chunhui Xu,Elen S. Rosler,Jianjie Jiang,Jane S. Lebkowski,Joseph D. Gold,Chris O'Sullivan,Karen Delavan-Boorsma,Michael Mok,Adrienne Bronstein,Melissa K. Carpenter +9 more
TL;DR: Cells in media containing Flt‐3L, thrombopoietin, and SCF, individually or in combination, showed almost complete differentiation after 6 weeks in culture, demonstrating that hESCs can be maintained in nonconditioned medium using growth factors.
Journal ArticleDOI
Formation of Human Myocardium in the Rat Heart from Human Embryonic Stem Cells
Michael A. Laflamme,Joseph B. Gold,Chunhui Xu,Mohammad Hassanipour,Elen S. Rosler,Veronica Muskheli,Charles E. Murry +6 more
TL;DR: Human embryonic stem cells can form human myocardium in the rat heart, permitting studies of humanMyocardial development and physiology and supporting the feasibility of their use in myocardial repair.