Author
Chunmei Li
Bio: Chunmei Li is an academic researcher from Texas Tech University. The author has contributed to research in topics: Phenanthroline & Catalysis. The author has an hindex of 10, co-authored 25 publications receiving 297 citations.
Topics: Phenanthroline, Catalysis, Chemistry, Pyridine, One-pot synthesis
Papers
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TL;DR: A series of unusual fused heterocyclic compound derivatives, consisting of a pyridine and a imidazole or pyrimidine core, with a bridgehead nitrogen, were successfully synthesized by a microwave-assisted, three-component domino reaction of aldehydes, enaminones, and malononnitrile.
Abstract: A series of unusual fused heterocyclic compound derivatives, consisting of a pyridine and a imidazole or pyrimidine core, with a bridgehead nitrogen, were successfully synthesized by a microwave-assisted, three-component domino reaction of aldehydes, enaminones, and malononnitrile. In this one-pot reaction, up to five new bonds were formed accompanied by generating the lactam group. This method has the advantages of short synthetic route, operational simplicity, increased safety for small-scale high-speed synthesis, and minimal environment impact.
74 citations
TL;DR: In this paper, reaction of arylidenemalononitriles, 1,3-indanedione, and mercaptoacetic acid or 4-methylbenzenethiol is successfully carried out using microwave heating.
38 citations
TL;DR: In this article, a facile and selective synthesis of polysubstituted pyrido[2,3-D]pyrimidines is accomplished via microwave-assisted multicomponent reactions controlled by the nature of solvent.
Abstract: A facile and selective synthesis of poly-substituted pyrido[2,3- D]pyrimidines is accomplished via microwave-assisted multicomponent reactions controlled by the nature of solvent. In addition, a possible mechanism accounting for the reaction is proposed.
31 citations
TL;DR: A series of pyrido[2,3-d]pyrimidine derivatives and related compounds were synthesized via the condensation reaction of an aldehyde, 2,6-diaminopyrimidine-4(3H)-one and either tetronic acid or 1,3,indanedione under ultrasonic irradiation without catalyst.
30 citations
TL;DR: Triaza-benzo[b]fluoren-6-one derivatives were synthesized via the three-component reaction of aldehyde, cyclohexane-1,3-dione compound and 2-aminobenzimidazole in water under microwave irradiation as discussed by the authors.
24 citations
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TL;DR: In this review, more than 220 published examples of microwave-assisted synthetic organic transformations from the 2004 to 2008 literature are discussed and more than 500 reaction schemes are presented in the Electronic Supplementary Material.
Abstract: Direct and rapid heating by microwave irradiation in combination with sealed vessel processing in many cases enables reactions to be carried out in a fraction of the time generally required using conventional conditions. This makes microwave chemistry an ideal tool for rapid reaction scouting and optimization of conditions, allowing very rapid progress through hypotheses–experiment–results iterations. The speed at which multiple variations of reaction conditions can be performed allows a morning discussion of “What should we try?” to become an after-lunch discussion of “What were the results” Not surprisingly, therefore, many scientists both in academia and industry have turned to microwave synthesis as a front-line methodology for their projects. In this review, more than 220 published examples of microwave-assisted synthetic organic transformations from the 2004 to 2008 literature are discussed. An additional ca. 500 reaction schemes are presented in the Electronic Supplementary Material, providing the reader with an overall number of ca. 930 references in this fast-moving and exciting field.
423 citations
386 citations
TL;DR: Recent advances on multicomponent domino reactions for the construction of five-, six-, and seven-membered heterocyclic skeletons and their multicyclic derivatives are covered.
Abstract: Multicomponent domino reactions (MDRs) serve as a rapid and efficient tool for the synthesis of versatile heterocycles, particularly those containing structural diversity and complexity, by a one-pot operation. These reactions can dramatically reduce the generation of chemical wastes, costs of starting materials, and the use of energy and manpower. Moreover, the reaction period can be substantially shortened. This Review covers recent advances on multicomponent domino reactions for the construction of five-, six-, and seven-membered heterocyclic skeletons and their multicyclic derivatives.
355 citations
TL;DR: In this article, the use of environmentally benign and inexpensive eutectic solvents (DESs) as solvent and catalyst in the field of organic chemistry is discussed and compared.
295 citations
TL;DR: A new four-component domino reaction has been discovered, easy to perform simply by mixing four common reactants and K(2)CO(3) in ethylene glycol under microwave irradiation.
Abstract: A new four-component domino reaction has been discovered. The reaction is easy to perform simply by mixing four common reactants and K2CO3 in ethylene glycol under microwave irradiation. The reaction proceeds rapidly and can be finished within 10−24 min with water as the major byproduct, making workup convenient. Four stereogenic centers with one quaternary carbon−amino function are controlled very well; the stereochemistry was unequivocally determined by X-ray structural analysis. The resulting pyrido[3,4-i]quinazoline derivatives are of importance for organic and medicinal research.
227 citations