C
Cicero Lee-Tian Chang
Researcher at National Chung Hsing University
Publications - 24
Citations - 869
Cicero Lee-Tian Chang is an academic researcher from National Chung Hsing University. The author has contributed to research in topics: Bidens pilosa & NOD mice. The author has an hindex of 14, co-authored 22 publications receiving 737 citations. Previous affiliations of Cicero Lee-Tian Chang include Academia Sinica.
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Journal ArticleDOI
Herbal Therapies for Type 2 Diabetes Mellitus: Chemistry, Biology, and Potential Application of Selected Plants and Compounds
Cicero Lee-Tian Chang,Yenshou Lin,Arlene P. Bartolome,Arlene P. Bartolome,Yi-Ching Chen,Shao Chih Chiu,Wen-Chin Yang +6 more
TL;DR: Blood glucose-lowering medicinal herbs that have the ability to modulate one or more of the pathways that regulate insulin resistance, β-cell function, GLP-1 homeostasis, and glucose (re)absorption are selected and discussed.
Journal ArticleDOI
Flavonoids, centaurein and centaureidin, from Bidens pilosa, stimulate IFN-γ expression
Shu-Lin Chang,Yi-Ming Chiang,Cicero Lee-Tian Chang,Hsu Hua Yeh,Hsu Hua Yeh,Lie-Fen Shyur,Yueh-Hsiung Kuo,Tung-Kung Wu,Wen-Chin Yang +8 more
TL;DR: Results showed that centaurein regulated IFN-gamma transcription, probably via NFAT and NFkappaB in T cells, in Jurkat cells.
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Anti-Hyperglycemic Properties of Crude Extract and Triterpenes from Poria cocos
TL;DR: Overall, the data suggest that the P. cocos extract and its triterpenes reduce postprandial blood glucose levels in db/db mice via enhanced insulin sensitivity irrespective of PPAR-γ.
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Polyacetylenic compounds and butanol fraction from Bidens pilosa can modulate the differentiation of helper T cells and prevent autoimmune diabetes in non-obese diabetic mice.
Shu-Lin Chang,Cicero Lee-Tian Chang,Yi-Ming Chiang,Rong Hong Hsieh,Chii Ruey Tzeng,Tung-Kung Wu,Huey-Kang Sytwu,Lie-Fen Shyur,Wen-Chin Yang +8 more
TL;DR: It is demonstrated that a butanol fraction of B. pilosa and its polyacetylenes can prevent diabetes plausibly via suppressing the differentiation of Th0 cells into Th1 cells and promoting that of Th 0cells into Th2 cells.
Journal ArticleDOI
Cytopiloyne, a novel polyacetylenic glucoside from Bidens pilosa, functions as a T helper cell modulator.
Yi-Ming Chiang,Cicero Lee-Tian Chang,Shu-Lin Chang,Shu-Lin Chang,Wen-Chin Yang,Wen-Chin Yang,Lie-Fen Shyur,Lie-Fen Shyur +7 more
TL;DR: Results suggest that cytopiloyne functions as a T cell modulator that may directly contribute to the ethnopharmacological effect of Bidens pilosa extract on preventing diabetes.