C
Cigall Kadoch
Researcher at Harvard University
Publications - 91
Citations - 6880
Cigall Kadoch is an academic researcher from Harvard University. The author has contributed to research in topics: Chromatin & Chromatin remodeling. The author has an hindex of 33, co-authored 79 publications receiving 4580 citations. Previous affiliations of Cigall Kadoch include Broad Institute & Stanford University.
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Journal ArticleDOI
Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy
Cigall Kadoch,Diana C. Hargreaves,Courtney Hodges,Laura Elias,Lena Ho,Jeff Ranish,Gerald R. Crabtree +6 more
TL;DR: It is demonstrated that mSWI/SNF is the most frequently mutated chromatin-regulatory complex (CRC) in human cancer, exhibiting a broad mutation pattern, similar to that of TP53, and proper functioning of polymorphic BAF complexes may constitute a major mechanism of tumor suppression.
Journal ArticleDOI
Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomics
Cigall Kadoch,Gerald R. Crabtree +1 more
TL;DR: Observations demonstrate that there is little redundancy in the oncogenic function of BAF complexes with the other remodeling complexes, underscoring their unique roles and highlighting potential avenues for therapeutic intervention in human cancer.
Journal ArticleDOI
Modular Organization and Assembly of SWI/SNF Family Chromatin Remodeling Complexes
Nazar Mashtalir,Nazar Mashtalir,Andrew R. D’Avino,Andrew R. D’Avino,Brittany C. Michel,Brittany C. Michel,Jie Luo,Joshua Pan,Joshua Pan,Jordan E. Otto,Jordan E. Otto,Hayley J. Zullow,Hayley J. Zullow,Zachary M. McKenzie,Rachel L. Kubiak,Roodolph St. Pierre,Roodolph St. Pierre,Alfredo M. Valencia,Alfredo M. Valencia,Steven J. Poynter,Steven J. Poynter,Seth H. Cassel,Seth H. Cassel,Jeffrey A. Ranish,Cigall Kadoch,Cigall Kadoch +25 more
TL;DR: This work elucidates the architecture and assembly pathway across three classes of mSWI/SNF complexes-canonical BRG1/BRM-associated factor (BAF), polybromo-associated BAF (PBAF, and newly defined ncBAF complexes) and defines the requirement of each subunit for complex formation and stability.
Journal ArticleDOI
Reversible Disruption of mSWI/SNF (BAF) Complexes by the SS18-SSX Oncogenic Fusion in Synovial Sarcoma
Cigall Kadoch,Gerald R. Crabtree +1 more
TL;DR: It is demonstrated that the SS18-SSX fusion protein competes for assembly with wild-type SS18, forming an altered complex lacking the tumor suppressor BAF47 (hSNF5), providing a potential foundation for therapeutic intervention.
Journal ArticleDOI
Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection.
Jin Wei,Mia Madel Alfajaro,Peter C DeWeirdt,Ruth E Hanna,William J. Lu-Culligan,Wesley L. Cai,Madison S. Strine,Shang Min Zhang,Vincent R. Graziano,Cameron O. Schmitz,Jennifer S. Chen,Madeleine C. Mankowski,Renata B. Filler,Neal G. Ravindra,Victor Gasque,Fernando J. de Miguel,Ajinkya Patil,Ajinkya Patil,Huacui Chen,Kasopefoluwa Y. Oguntuyo,Laura Abriola,Yulia V. Surovtseva,Robert C. Orchard,Benhur Lee,Brett D. Lindenbach,Katerina Politi,David van Dijk,Cigall Kadoch,Cigall Kadoch,Matthew D. Simon,Qin Yan,John G. Doench,Craig B. Wilen +32 more
TL;DR: It is shown that small molecule antagonists of identified gene products inhibited SARS-CoV-2 infection in monkey and human cells, demonstrating the conserved role of these genetic hits across species.