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Cihan Şen

Bio: Cihan Şen is an academic researcher from Çankırı Karatekin University. The author has contributed to research in topics: Carbonic anhydrase II & Tyrosinase. The author has an hindex of 2, co-authored 2 publications receiving 35 citations.

Papers
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Journal ArticleDOI
TL;DR: In this paper, new Schiff bases were synthesized (Z)-4-((4-(diethylamino)benzylidene)amino)-N-(3,4-dimethylisoxazol-5-yl)benzenesulfonamide (L1) and (Z]-4-(4-(dimethylamino), amino amino) amino)-n-(5-methylisoxosol-3-yl), N-(5 -methylisocazol)-3 -yl)benedienesulfoneamide (

45 citations

Journal ArticleDOI
TL;DR: In this paper, the synthesis of new Schiff bases (E) N-(3,4-dimethylisoxazol-5-yl)-4-((2-hydroxy-4-methoxybenzylidene)amino)benzenesulfonamide (L2), N-(5-methylisoxozol-3-yl)benzene sulfonamide(L3), and substituted salicylaldehydes and their Pd (II), Cu (II) complexes were synthesized for the first time.

30 citations


Cited by
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Journal ArticleDOI
TL;DR: The theoretical calculations of Benzyl-3-N-(2,4,5-trimethoxyphenylmethylene)hydrazinecarbodithioate and in silico studies predicted that the compound has good drug like character.

124 citations

Journal ArticleDOI
TL;DR: The pro-apoptotic mechanism for the active compound L5 was evaluated by fluorescence microscopy, cell cycle analysis, caspase-9 and -3 activity, reactive oxygen species production, and DNA binding studies that further strengthen the results of that L5 is a potent drug against cancer.
Abstract: Five Schiff bases, 2-((3-chlorophenylimino)methyl)-5-(diethylamino)phenol (L1), 2-((2,4-dichlorophenylimino)methyl)-5-(diethylamino)phenol (L2), 5-(diethylamino)-2-((3,5-dimethylphenylimino)methyl)phenol (L3), 2-((2-chloro-4-methylphenylimino)methyl)-5-(diethylamino)phenol (L4), and 5-(diethylamino)-2-((2,6-diethylphenylimino)methyl)phenol (L5) were synthesized and characterized by elemental analysis, FT-IR, 1H and 13C NMR spectroscopy. Three of the compounds (L1, L2, and L4) were analyzed by single crystal X-ray diffraction: L1 and L2 crystallized in orthorhombic P212121 and Pca21 space group, respectively, while L4 crystallized in monoclinic P21/c space group. Theoretical investigations were performed for all the synthesized compounds to evaluate the structural details. Drug-DNA interaction studies results from UV-Vis spectroscopy and electrochemistry complement that the compounds bind to DNA through electrostatic interactions. The cytotoxicity of the synthesized compounds was studied against cancer cell lines (HeLa and MCF-7) and a normal cell line (BHK-21) by means of an MTT assay compared to carboplatin, featuring IC50 values in the micromolar range. The pro-apoptotic mechanism for the active compound L5 was evaluated by fluorescence microscopy, cell cycle analysis, caspase-9 and -3 activity, reactive oxygen species production, and DNA binding studies that further strengthen the results of that L5 is a potent drug against cancer.Communicated by Ramaswamy H. Sarma.

47 citations

Journal ArticleDOI
TL;DR: In this paper, new Schiff bases were synthesized (Z)-4-((4-(diethylamino)benzylidene)amino)-N-(3,4-dimethylisoxazol-5-yl)benzenesulfonamide (L1) and (Z]-4-(4-(dimethylamino), amino amino) amino)-n-(5-methylisoxosol-3-yl), N-(5 -methylisocazol)-3 -yl)benedienesulfoneamide (

45 citations

Journal ArticleDOI
TL;DR: The 2-amino-4-(4-aminophenyl)thiophene-3-carbonitrile (AI3) was synthesized and characterized experimentally by FT-IR, NMR and theoretically by quantum chemical calculations.

41 citations

Journal ArticleDOI
TL;DR: In this paper, the synthesis and biological evaluation of new Schiff bases incorporating (2]-hydroxy-5-methylbenzaldehyde sulfisoxazole (S2M-S1) and (S1M)-S1 were presented, and the synthesized compounds were characterized by FT-IR, 1H 13C NMR, LC-MS, magnetic susceptibility and conductivity measurements.

28 citations