Author
Claire Davey
Bio: Claire Davey is an academic researcher. The author has contributed to research in topics: Clinical trial & Patient satisfaction. The author has an hindex of 3, co-authored 3 publications receiving 2225 citations.
Papers
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Journal Article•
TL;DR: This research highlights the need to understand more fully the rationale behind the continued use of these devices, as well as the barriers to their adoption.
Abstract: s. Outcome research 249 Questionnaire 63,152 Would pick up refer-
1,638 citations
693 citations
01 Jan 1970
33 citations
Cited by
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University of Washington1, University of Rochester2, AstraZeneca3, University of Queensland4, Pfizer5, Tufts University6, University of Pennsylvania7, Endo International plc8, University Health Network9, Harvard University10, Purdue Pharma11, Novartis12, National Institutes of Health13, Dalhousie University14, GlaxoSmithKline15, Food and Drug Administration16, Élan17, Abbott Laboratories18, University of California, San Diego19, United States Department of Veterans Affairs20
TL;DR: In this article, the authors provide recommendations for the core outcome domains that should be considered by investigators conducting clinical trials of the efficacy and effectiveness of treatments for chronic pain, and develop a core set of outcome domains would facilitate comparison and pooling of d
Abstract: Objective. To provide recommendations for the core outcome domains that should be considered by investigators conducting clinical trials of the efficacy and effectiveness of treatments for chronic pain. Development of a core set of outcome domains would facilitate comparison and pooling of d
3,476 citations
TL;DR: The design and execution of research required to address the additional problems resulting from evaluation of complex interventions, those “made up of various interconnecting parts,” are examined.
Abstract: Randomised controlled trials are widely accepted as the most reliable method of determining effectiveness, but most trials have evaluated the effects of a single intervention such as a drug. Recognition is increasing that other, non-pharmacological interventions should also be rigorously evaluated.1-3 This paper examines the design and execution of research required to address the additional problems resulting from evaluation of complex interventions—that is, those “made up of various interconnecting parts.”4 The issues dealt with are discussed in a longer Medical Research Council paper (www.mrc.ac.uk/complex_packages.html). We focus on randomised trials but believe that this approach could be adapted to other designs when they are more appropriate.
#### Summary points
Complex interventions are those that include several components
The evaluation of complex interventions is difficult because of problems of developing, identifying, documenting, and reproducing the intervention
A phased approach to the development and evaluation of complex interventions is proposed to help researchers define clearly where they are in the research process
Evaluation of complex interventions requires use of qualitative and quantitative evidence
There are specific difficulties in defining, developing, documenting, and reproducing complex interventions that are subject to more variation than a drug. A typical example would be the design of a trial to evaluate the benefits of specialist stroke units. Such a trial would have to consider the expertise of various health professionals as well as investigations, drugs, treatment guidelines, and arrangements for discharge and follow up. Stroke units may also vary in terms of organisation, management, and skill mix. The active components of the stroke unit may be difficult to specify, making it difficult to replicate the intervention. The box gives other examples of complex interventions.
#### Examples of complex interventions
Service delivery and organisation:
Stroke units
Hospital at home
Interventions directed at health professionals' behaviour:
Strategies for implementing guidelines
Computerised decision support
Community interventions:
Community …
3,235 citations
University of Rochester1, University of Washington2, University of Pennsylvania3, Johns Hopkins University4, Harvard University5, Yale University6, Ludwig Maximilian University of Munich7, AstraZeneca8, University of Queensland9, Tufts University10, Merck & Co.11, National Institutes of Health12, Endo International plc13, Food and Drug Administration14, University of Toronto15, Purdue Pharma16
2,441 citations
TL;DR: It is possible that fall‐prevention strategies have limited effect on falls that result in injuries or are ineffective in populations who are at a higher risk of injury.
Abstract: The prevention of injury associated with falls in older people is a public health target in many countries around the world. Although there is good evidence that interventions such as multifactorial fall prevention and individually prescribed exercise are effective in reducing falls, the effect on serious injury rates is unclear. Historically, trials have not been adequately powered to detect injury endpoints, and variations in case definition across trials have hindered meta-analysis. It is possible that fall-prevention strategies have limited effect on falls that result in injuries or are ineffective in populations who are at a higher risk of injury. Further research is required to determine whether fall-prevention interventions can reduce serious injuries. Prevention of Falls Network Europe (ProFaNE) is a collaborative project to reduce the burden of fall injury in older people through excellence in research and promotion of best practice (www.profane.eu.org). The European Commission funds the network, which links clinicians, members of the public, and researchers worldwide. The aims are to identify major gaps in knowledge in fall injury prevention and to facilitate the collaboration necessary for large-scale clinical research activity, including clinical trials, comparative research, and prospective meta-analysis. Work is being undertaken in a 4-year program. As a first step, the development of a common set of outcome definitions and measures for future trials or meta-analysis was considered.
1,725 citations
TL;DR: This guideline provides a synopsis of best clinical practices in the rehabilitative care of adults recovering from stroke to reduce the risk of downstream medical morbidity resulting from immobility, depression, loss of autonomy, and reduced functional independence.
Abstract: Purpose—The aim of this guideline is to provide a synopsis of best clinical practices in the rehabilitative care of adults recovering from stroke. Methods—Writing group members were nominated by th...
1,679 citations