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Claire M. Steppan
Researcher at Pfizer
Publications - 57
Citations - 11399
Claire M. Steppan is an academic researcher from Pfizer. The author has contributed to research in topics: Resistin & Biology. The author has an hindex of 26, co-authored 49 publications receiving 9372 citations. Previous affiliations of Claire M. Steppan include University of Pittsburgh & University of Pennsylvania.
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Journal ArticleDOI
The hormone resistin links obesity to diabetes
Claire M. Steppan,Shannon T. Bailey,Savitha Bhat,Elizabeth J. Brown,Ronadip R. Banerjee,Christopher M. Wright,Hiralben R. Patel,Rexford S. Ahima,Mitchell A. Lazar +8 more
TL;DR: It is shown that adipocytes secrete a unique signalling molecule, which is named resistin (for resistance to insulin), which circulating resistin levels are decreased by the anti-diabetic drug rosiglitazone, and increased in diet-induced and genetic forms of obesity.
Posted ContentDOI
An oral SARS-CoV-2 Mpro inhibitor clinical candidate for the treatment of COVID-19.
Dafydd R. Owen,Charlotte Moira Norfor Allerton,Annaliesa S. Anderson,Lisa Aschenbrenner,Melissa Avery,Simon Berritt,Britton Boras,Rhonda D. Cardin,Anthony Carlo,Karen J. Coffman,Alyssa Dantonio,Li Di,Heather Eng,RoseAnn Ferre,Ketan S. Gajiwala,Scott A. Gibson,Samantha Elizabeth Greasley,Brett L. Hurst,Eugene P. Kadar,Amit S. Kalgutkar,Jack C. Lee,Jisun Lee,Wei Liu,Stephen W. Mason,Stephen Noell,Jonathan J. Novak,R. Scott Obach,Kevin Ogilvie,Nandini Chaturbhai Patel,Martin Pettersson,Devendra K. Rai,Matthew R. Reese,Matthew F. Sammons,Jean G. Sathish,Ravi Shankar P. Singh,Claire M. Steppan,Al E. Stewart,Jamison B. Tuttle,Lawrence W. Updyke,Patrick Robert Verhoest,Liuqing Wei,Qingyi Yang,Yuao Zhu +42 more
TL;DR: The worldwide outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome (SARS-CoV-2) has become a global pandemic as discussed by the authors.
Journal ArticleDOI
Regulation of Fasted Blood Glucose by Resistin
Ronadip R. Banerjee,Shamina M. Rangwala,Jennifer S. Shapiro,A. Sophie Rich,Ben Rhoades,Yong Qi,Juan Wang,Michael W. Rajala,Alessandro Pocai,Phillipp E. Scherer,Claire M. Steppan,Rexford S. Ahima,Silvana Obici,Luciano Rossetti,Mitchell A. Lazar +14 more
TL;DR: It is reported that mice lacking the adipocyte hormone resistin exhibit low blood glucose levels after fasting, due to reduced hepatic glucose production, suggesting a role for resistin in mediating hyperglycemia associated with obesity.
Journal ArticleDOI
A family of tissue-specific resistin-like molecules
Claire M. Steppan,Elizabeth J. Brown,Christopher M. Wright,Savitha Bhat,Ronadip R. Banerjee,Charlotte Y. Dai,Gregory H. Enders,Debra G. Silberg,Xiaoming Wen,Gary D. Wu,Mitchell A. Lazar +10 more
TL;DR: The RELMs together with resistin comprise a class of tissue-specific signaling molecules that share a cysteine composition and other signature features and suggest a role in intestinal proliferation.
Journal ArticleDOI
Resistin and obesity-associated insulin resistance
TL;DR: In this article, an adipose-specific secreted protein called resistin was found to have a potential link between TZDs, obesity and insulin resistance in the mouse, with increased levels in obesity and has effects on glucose homeostasis that oppose those of insulin.