Claire Taylor

TL;DR: Mutations in FGFR3 and Ras gene mutation may represent alternative means to confer the same phenotype on UCC cells, and if these events have biological equivalence, Ras mutant invasive UCC may represent a novel subgroup.

TL;DR: No significant differences were seen between VHL subgroups with regard to clinicopathologic features including stage, grade, tumor size, cancer-free and overall survival, with the exception of a significant association between loss of heterozygosity and grade, although a possible trend for survival differences based on mutation location was apparent.

TL;DR: It is shown that HIF-alpha is up-regulated in the majority of CC-RCCs, and that the pattern of expression is biased toward the Hif-2alpha isoform, suggesting that activation of the HIF pathway is functionally important in CC- RCC development and might provide a new therapeutic target.

TL;DR: The lack of redundancy of alterations suggests that single-agent PI3K-targeted therapy may not be successful in these cancers, and a well-characterized series of cell lines are provided for use in preclinical studies of targeted agents.

TL;DR: The prevalence of newly diagnosed CIN3 increased with time since last normal smear, indicating that most cases persist for several years, while the prevalence of lesser abnormality was almost independent of screening interval.