C
Clara Correia-Melo
Researcher at Francis Crick Institute
Publications - 31
Citations - 3142
Clara Correia-Melo is an academic researcher from Francis Crick Institute. The author has contributed to research in topics: Senescence & Medicine. The author has an hindex of 14, co-authored 26 publications receiving 2231 citations. Previous affiliations of Clara Correia-Melo include Newcastle University & University of Cambridge.
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Journal ArticleDOI
Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence
Graeme Hewitt,Diana Jurk,Francisco D.M. Marques,Clara Correia-Melo,Timothy Hardy,Agata Gackowska,Rhys Anderson,Morgan Taschuk,Jelena Mann,João F. Passos +9 more
TL;DR: It is shown, using immuno-fluorescent in situ hybridization and ChIP, that up to half of the DNA damage foci in stress-induced senescence are located at telomere irrespective of telomerase activity, and that all persistent foci are associated with telomeres.
Journal ArticleDOI
Chronic inflammation induces telomere dysfunction and accelerates ageing in mice
Diana Jurk,Caroline L. Wilson,João F. Passos,Fiona Oakley,Clara Correia-Melo,Laura C. Greaves,Gabriele Saretzki,Chris Fox,Conor Lawless,Rhys Anderson,Graeme Hewitt,Sylvia L.F. Pender,Nicola Fullard,Glyn Nelson,Jelena Mann,Bart van de Sluis,Derek A. Mann,Thomas von Zglinicki +17 more
TL;DR: It is shown that chronic, progressive low-grade inflammation induced by knockout of the nfkb1 subunit of the transcription factor NF-κB induces premature ageing in mice, and frequency of senescent cells in liver and intestinal crypts quantitatively predict mean and maximum lifespan in both short- and long-lived mice cohorts.
Journal ArticleDOI
Mitochondria are required for pro‐ageing features of the senescent phenotype
Clara Correia-Melo,Clara Correia-Melo,Francisco D.M. Marques,Rhys Anderson,Graeme Hewitt,Rachael N. Hewitt,John J. Cole,Bernadette Carroll,Satomi Miwa,Jodie Birch,Alina Merz,Michael D. Rushton,Michelle Charles,Diana Jurk,Stephen W.G. Tait,Rafal Czapiewski,Laura C. Greaves,Glyn Nelson,Mohammad Bohlooly-Y,Sergio Rodriguez-Cuenca,Antonio Vidal-Puig,Derek A. Mann,Gabriele Saretzki,Giovanni Quarato,Douglas R. Green,Peter D. Adams,Thomas von Zglinicki,Viktor I. Korolchuk,João F. Passos +28 more
TL;DR: The results suggest that mitochondria are a candidate target for interventions to reduce the deleterious impact of senescence in ageing tissues.
Journal ArticleDOI
Length‐independent telomere damage drives post‐mitotic cardiomyocyte senescence
Rhys Anderson,Anthony B. Lagnado,Damien Maggiorani,Anna Walaszczyk,Emily Dookun,James Chapman,Jodie Birch,Hanna Salmonowicz,Mikolaj Ogrodnik,Diana Jurk,Diana Jurk,Carole J. Proctor,Clara Correia-Melo,Stella Victorelli,Edward Fielder,Rolando Berlinguer-Palmini,A Owens,Laura C. Greaves,Kathy L Kolsky,Angelo Parini,Victorine Douin-Echinard,Nathan K. LeBrasseur,Helen M. Arthur,Simon Tual-Chalot,Marissa J. Schafer,Carolyn M Roos,Jordan D. Miller,Neil Robertson,Jelena Mann,Peter D. Adams,Peter D. Adams,Tamara Tchkonia,James L. Kirkland,Jeanne Mialet-Perez,Gavin D. Richardson,João F. Passos,João F. Passos +36 more
TL;DR: A mechanism by which senescence can occur and contribute to age‐related myocardial dysfunction and in the wider setting to ageing in post‐mitotic tissues is described.
Journal ArticleDOI
Telomeres, oxidative stress and inflammatory factors: partners in cellular senescence?
TL;DR: The current understanding of cellular senescence is described, the intricate pathways linking the DDR, ROS and SASP are examined, and their impact on the stability of the senescent phenotype is evaluated.