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Claudia A. Landis
Researcher at University of California, San Francisco
Publications - 6
Citations - 2586
Claudia A. Landis is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: G protein & Adenylyl cyclase. The author has an hindex of 6, co-authored 6 publications receiving 2534 citations. Previous affiliations of Claudia A. Landis include Cetus Corporation.
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Journal ArticleDOI
GTPase inhibiting mutations activate the α chain of G s and stimulate adenylyl cyclase in human pituitary tumours
TL;DR: A subset of growth hormone-secreting human pituitary tumours carries somatic mutations that inhibit GTPase activity of a G protein α chain, αs, which results in the activation of adenylyl cyclase, which bypasses the cells' normal requirement for trophic hormone.
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Two G protein oncogenes in human endocrine tumors
John Lyons,Claudia A. Landis,Claudia A. Landis,Griffith R. Harsh,Lucia Vallar,Kurt Grünewald,Hans Feichtinger,Quan-Yang Duh,Orlo H. Clark,Ernest S. Kawasaki,Henry R. Bourne,Henry R. Bourne,Frank McCormick +12 more
TL;DR: Findings suggest that human tumors may harbor oncogenic mutations in various G protein alpha chain genes, referred to as gip2.
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Clinical characteristics of acromegalic patients whose pituitary tumors contain mutant Gs protein.
Claudia A. Landis,Griffith R. Harsh,John Lyons,Richard L. Davis,Frank McCormick,Henry R. Bourne +5 more
TL;DR: The activating mutations identify a subgroup of GH-secreting pituitary tumors that probably arise from a shared oncogenic mechanism.
Journal ArticleDOI
Hydrolysis of GTP by the α‐chain of Gs and other GTP binding proteins
TL;DR: It is proposed that this domain of αs constitutes an intrinsic activator of GTP hydrolysis, and that it performs a function analogous to that performed for EF‐Tu by the programmed ribosome and for p21ras by the recently discovered GTPase‐activating protein.
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Constitutively active stimulatory G-protein alpha s in beta-cells of transgenic mice causes counterregulation of the increased adenosine 3',5'-monophosphate and insulin secretion
Yan Hui Ma,Claudia A. Landis,Nadia K. Tchao,Jian Wang,Gail G. Rodd,Douglas Hanahan,Henry R. Bourne,Gerold M. Grodsky +7 more
TL;DR: It is concluded that expression of constitutively active alpha s mutant in pancreatic beta-cells of transgenic mice is functionally effective, causing the physiological phenotype of increased islet cAMP and insulin secretion.