Claudia Batram

TL;DR: The data suggest that the detection of the numerous bitter chemicals is related to the molecular receptive ranges of hTAS2Rs, and some receptors recognized only few agonists, others displayed moderate or extreme tuning broadness.

TL;DR: This work employed a high-throughput screening approach to discover a novel bitter receptor antagonist (GIV3727) that inhibits activation of hTAS2R31 by saccharin and acesulfame K, two common artificial sweeteners.

TL;DR: The subjects perceived the bitterness of the investigated compounds at higher concentrations than those predicted by the results of the in vitro experiments, and differences were shown to be due, at least in part, to interactions of the bitter substances with the oral mucosa.

TL;DR: Results show that receptor oligomerization occurs between TAS2R bitter taste receptors; however, functional consequences of hetero-oligomerization were not obvious.

TL;DR: Two natural bitter terpenoids are identified that are agonists for the orphan receptor hTAS2R50, the most distant member of the bitter taste receptors subfamily, and insights into the general breadth of tuning, functional redundancies, and relationships between pharmacological activation patterns and amino acid homologies for this receptor subfamily are presented.