Claudia Grajeda-Iglesias

TL;DR: It is demonstrated that ketogenic diet induces a 3HB-mediated antineoplastic effect that relies on T cell–mediated cancer immunosurveillance.

TL;DR: In this paper, the authors report alterations in the plasma metabolome reflecting the clinical presentation of COVID-19 patients with mild (ambulatory) diseases, moderate disease (radiologically confirmed pneumonitis, hospitalization and oxygen therapy), and critical disease (in intensive care).

TL;DR: Investigating the time-dependent effects of oral administration of Akk and other bacteria to mice on the metabolome of the ileum, colon, liver and blood plasma found that pasteurized Akk (Akk-past) was more efficient than live Akk in elevating the intestinal concentrations of polyamines, short-chain fatty acids, 2-hydroxybutyrate, as well multiple bile acids, which also increased in the circulation.

TL;DR: In this paper, the authors found that malignant disease favors the magnitude and duration of viral RNA shedding concomitant with prolonged serum elevations of type 1 IFN that anticorrelated with anti-RBD IgG antibodies, and that low lymphocyte counts correlated with chronic SARS-CoV-2 RNA shedding, COVID-19 severity, and a higher risk of cancer-related death in the first and second surge of the pandemic.

TL;DR: In this article, the authors investigated the serum metabolome of 204 cancer patients enrolled in the ONCOVID trial and found that the levels of acetylated polyamines alone or in aggregate were elevated in severe Covid-19 cancer patients requiring hospitalization as compared to uninfected cancer patients or cancer patients with mild Covid19.