C
Claudia Lucia Martins Silva
Researcher at Federal University of Rio de Janeiro
Publications - 64
Citations - 1127
Claudia Lucia Martins Silva is an academic researcher from Federal University of Rio de Janeiro. The author has contributed to research in topics: Receptor & Endothelial stem cell. The author has an hindex of 17, co-authored 60 publications receiving 980 citations. Previous affiliations of Claudia Lucia Martins Silva include University of São Paulo & Université catholique de Louvain.
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Journal ArticleDOI
CD39 limits P2X7 receptor inflammatory signaling and attenuates sepsis-induced liver injury.
Luiz Eduardo Baggio Savio,Luiz Eduardo Baggio Savio,Paola A. Mello,Paola A. Mello,Vanessa Ribeiro Figliuolo,Thiago F. de Avelar Almeida,Patricia T. Santana,Suellen D. S. Oliveira,Suellen D. S. Oliveira,Claudia Lucia Martins Silva,Linda Feldbrügge,Eva Csizmadia,Richard D. Minshall,Maria Serena Longhi,Yan Wu,Simon C. Robson,Robson Coutinho-Silva +16 more
TL;DR: Boosting of CD39 would suppress P2X7 responses and trigger adenosinergic signaling to limit systemic inflammation and restore liver homeostasis during the acute phase of sepsis.
Journal ArticleDOI
Genetic algorithm development for multi-objective optimization of batch free-radical polymerization reactors
TL;DR: An improved genetic algorithm approach, based on a new ranking strategy, has been proposed to conduct multi-objective optimization of chemical engineering problems, and proved to be robust, handling satisfactorily multi-modal and multidimensional problems.
Journal ArticleDOI
Melatonin inhibits LPS-induced NO production in rat endothelial cells
Eduardo Koji Tamura,Erika Cecon,Alex Willian Arantes Monteiro,Claudia Lucia Martins Silva,Regina P. Markus +4 more
TL;DR: It is shown that concentrations compatible with nocturnal melatonin surge (nm) did not interfere with the activity of iNOS, and it is proposed that extra‐pineal melatonin could have a protective effect against tissue injury.
Journal ArticleDOI
Melatonin inhibits endothelial nitric oxide production in vitro.
TL;DR: It is shown that melatonin reduces NO production induced by bradykinin by a mechanism upstream to the interaction of Ca2+–calmodulin with NOS, which might be the basis of the diurnal variation in endothelial cell function.
Journal ArticleDOI
Melatonin inhibits nitric oxide production by microvascular endothelial cells in vivo and in vitro.
Claudia Lucia Martins Silva,Eduardo Koji Tamura,S M D Macedo,Erika Cecon,L. Bueno-Alves Jr.,Sandra Helena Poliselli Farsky,Zulma S. Ferreira,Regina P. Markus +7 more
TL;DR: This investigation extended the observation that melatonin inhibits bradykinin‐induced NO production by endothelial cells in vitro to an in vivo condition and explored the mechanism of action of melatonin.