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Claudia P. Arevalo
Researcher at University of Pennsylvania
Publications - 22
Citations - 3156
Claudia P. Arevalo is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Immune system & Antibody. The author has an hindex of 13, co-authored 20 publications receiving 1667 citations.
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Journal ArticleDOI
Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications
Divij Mathew,Josephine R. Giles,Amy E. Baxter,Derek A. Oldridge,Allison R. Greenplate,Jennifer E. Wu,Cécile Alanio,Leticia Kuri-Cervantes,M. Betina Pampena,Kurt D'Andrea,Sasikanth Manne,Zeyu Chen,Yinghui Jane Huang,John P. Reilly,Ariel R. Weisman,Caroline A. G. Ittner,Oliva Kuthuru,Jeanette Dougherty,Kito Nzingha,Nicholas Han,Justin Kim,Ajinkya Pattekar,Eileen C. Goodwin,Elizabeth M. Anderson,Madison E. Weirick,Sigrid Gouma,Claudia P. Arevalo,Marcus J. Bolton,Fang Chen,Simon F. Lacey,Holly Ramage,Sara Cherry,Scott E. Hensley,Sokratis A. Apostolidis,Alexander C. Huang,Laura A. Vella,Laura A. Vella,Michael R. Betts,Nuala J. Meyer,E. John Wherry +39 more
TL;DR: High-dimensional flow cytometry of hospitalized COVID-19 patients found three prominent and distinct immunotypes that are related to disease severity and clinical parameters, and a compendium of immune cell information and roadmaps for potential therapeutic interventions is provided.
Journal ArticleDOI
Comprehensive mapping of immune perturbations associated with severe COVID-19.
Leticia Kuri-Cervantes,M. Betina Pampena,Wenzhao Meng,Aaron M. Rosenfeld,Caroline A. G. Ittner,Ariel R. Weisman,R.S. Agyekum,Divij Mathew,Amy E. Baxter,Laura A. Vella,Laura A. Vella,Oliva Kuthuru,Sokratis A. Apostolidis,Sokratis A. Apostolidis,Luanne Bershaw,Jeanette Dougherty,Allison R. Greenplate,Ajinkya Pattekar,Ajinkya Pattekar,Justin Kim,Nicholas Han,Sigrid Gouma,Madison E. Weirick,Claudia P. Arevalo,Marcus J. Bolton,Eileen C. Goodwin,Elizabeth M. Anderson,Scott E. Hensley,Tiffanie K. Jones,Nilam S. Mangalmurti,Eline T. Luning Prak,E. John Wherry,Nuala J. Meyer,Michael R. Betts +33 more
TL;DR: The neutrophil to lymphocyte ratio is found to be a prognostic biomarker of disease severity and organ failure and broad innate and adaptive leukocyte perturbations that distinguish dysregulated host responses in severe SARS-CoV-2 infection and warrant therapeutic investigation.
Journal ArticleDOI
Seasonal human coronavirus antibodies are boosted upon SARS-CoV-2 infection but not associated with protection.
Elizabeth M. Anderson,Eileen C. Goodwin,Anurag Verma,Claudia P. Arevalo,Marcus J. Bolton,Madison E. Weirick,Sigrid Gouma,Christopher M McAllister,Shannon R. Christensen,JoEllen Weaver,Philip Hicks,Tomaz B. Manzoni,Oluwatosin Oniyide,Holly Ramage,Divij Mathew,Amy E. Baxter,Derek A. Oldridge,Allison R. Greenplate,Jennifer E. Wu,Cécile Alanio,Kurt D'Andrea,Oliva Kuthuru,Jeanette Dougherty,Ajinkya Pattekar,Justin Kim,Nicholas Han,Sokratis A. Apostolidis,Alexander C. Huang,Laura A. Vella,Laura A. Vella,Leticia Kuri-Cervantes,M. Betina Pampena,Michael R. Betts,E. John Wherry,Nuala J. Meyer,Sara Cherry,Paul Bates,Daniel J. Rader,Scott E. Hensley +38 more
TL;DR: In this paper, the authors quantified levels of SARS-CoV-2-reactive antibodies and hCoVreactive antibody in serum samples collected from 431 individuals before the COVID-19 pandemic, and then quantified pre-pandemic antibody levels in serum from a separate cohort of 251 individuals who became PCR-confirmed infected with SARS CoV 2.
Journal ArticleDOI
Assessment of Maternal and Neonatal Cord Blood SARS-CoV-2 Antibodies and Placental Transfer Ratios.
Dustin D. Flannery,Dustin D. Flannery,Sigrid Gouma,Miren B. Dhudasia,Sagori Mukhopadhyay,Sagori Mukhopadhyay,Madeline R. Pfeifer,Emily C. Woodford,Jourdan E. Triebwasser,Jeffrey S. Gerber,Jeffrey S. Morris,Madison E. Weirick,Christopher M McAllister,Marcus J. Bolton,Claudia P. Arevalo,Elizabeth M. Anderson,Eileen C. Goodwin,Scott E. Hensley,Karen M. Puopolo,Karen M. Puopolo +19 more
TL;DR: In this paper, the authors assess the association between maternal and neonatal SARS-CoV-2-specific antibody concentrations and demonstrate the potential for maternally derived antibodies to provide neonatal protection from coronavirus disease 2019.
Journal ArticleDOI
Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared to adult and pediatric COVID-19.
Laura A. Vella,Laura A. Vella,Josephine R. Giles,Amy E. Baxter,Derek A. Oldridge,Derek A. Oldridge,Caroline Diorio,Leticia Kuri-Cervantes,Cécile Alanio,M. Betina Pampena,Jennifer E. Wu,Zeyu Chen,Yinghui Jane Huang,Elizabeth M. Anderson,Sigrid Gouma,Kevin O McNerney,Julie Chase,Chakkapong Burudpakdee,Jessica H. Lee,Sokratis A. Apostolidis,Alexander C. Huang,Divij Mathew,Oliva Kuthuru,Eileen C. Goodwin,Madison E. Weirick,Marcus J. Bolton,Claudia P. Arevalo,Andre Ramos,Cristina Jasen,Peyton Conrey,Samir Sayed,Heather M. Giannini,Kurt D'Andrea,Nuala J. Meyer,Edward M. Behrens,Edward M. Behrens,Hamid Bassiri,Hamid Bassiri,Scott E. Hensley,Sarah E. Henrickson,David T. Teachey,Michael R. Betts,E. John Wherry +42 more
TL;DR: In this article, the authors analyzed peripheral blood immune responses in hospitalized SARS-CoV-2 infected pediatric patients (pediatric COVID-19) and patients with MIS-C.