Clemens Steegborn

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: It is shown that Sirt3 can deacetylate and thereby activate a central metabolic regulator in the mitochondrial matrix, glutamate dehydrogenase, and that the N- and C-terminal regions of Sirt 3 regulate its activity against glutamate dehydrogensase and a peptide substrate, indicating roles for these regions in substrate recognition and Sirtuin regulation.

TL;DR: A comparison of the biochemical, structural and regulatory characteristics of the two mammalian AC families reveals the mechanisms underlying their different properties but also illustrates many unifying themes for these evolutionary related signaling enzymes.

TL;DR: This work elucidates SIRT4 as an important regulator of lipid homeostasis, identifies MCD as a Sirtuin target, and deepens the understanding of the malonyl CoA regulatory axis.

TL;DR: Interestingly, hnRNP-R is predominantly located in axons of motor neurons and co-localizes with Smn in this cellular compartment, which could provide a key to understand a motor neuron-specific Smn function in SMA.