C
Clifford B. Saper
Researcher at Beth Israel Deaconess Medical Center
Publications - 415
Citations - 76416
Clifford B. Saper is an academic researcher from Beth Israel Deaconess Medical Center. The author has contributed to research in topics: Hypothalamus & Circadian rhythm. The author has an hindex of 136, co-authored 406 publications receiving 72203 citations. Previous affiliations of Clifford B. Saper include Robarts Research Institute & University of Texas Health Science Center at San Antonio.
Papers
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Journal ArticleDOI
Narcolepsy in orexin knockout mice: Molecular genetics of sleep regulation
Richard M. Chemelli,Jon T. Willie,Christopher M. Sinton,Joel K. Elmquist,Thomas E. Scammell,Charlotte E. Lee,James A. Richardson,S. Clay Williams,Yumei Xiong,Yaz Y. Kisanuki,Thomas Fitch,Masamitsu Nakazato,Robert E. Hammer,Clifford B. Saper,Masashi Yanagisawa +14 more
TL;DR: It is proposed that orexin regulates sleep/wakefulness states, and that Orexin knockout mice are a model of human narcolepsy, a disorder characterized primarily by rapid eye movement (REM) sleep dysregulation.
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Hypothalamic regulation of sleep and circadian rhythms
TL;DR: These findings explain how various drugs affect sleep and wakefulness, and provide the basis for a wide range of environmental influences to shape wake–sleep cycles into the optimal pattern for survival.
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The sleep switch: hypothalamic control of sleep and wakefulness
TL;DR: A model is proposed in which wake- and sleep-promoting neurons inhibit each other, which results in stable wakefulness and sleep and disruption of wake- or sleep- Promoting pathways results in behavioral state instability.
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Differential expression of orexin receptors 1 and 2 in the rat brain.
Jacob Marcus,Carl J. Aschkenasi,Charlotte E. Lee,Richard M. Chemelli,Clifford B. Saper,Masashi Yanagisawa,Joel K. Elmquist +6 more
TL;DR: The differential distribution of oxin receptors is consistent with the proposed multifaceted roles of orexin in regulating homeostasis and may explain the unique role of the OX2R receptor in regulating sleep state stability.
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From lesions to leptin: hypothalamic control of food intake and body weight.
TL;DR: The availability of these molecular tools, coupled with tract tracing, has resulted in striking progress in dissecting an extensive network of hypothalamic circuitry that regulates feeding, and the outline of the hypothalamic system for regulation of feeding is now more clear.