Author
Clifford George
Other affiliations: Ben-Gurion University of the Negev, Naval Surface Warfare Center, Thiokol ...read more
Bio: Clifford George is an academic researcher from United States Naval Research Laboratory. The author has contributed to research in topics: Crystal structure & Bicyclic molecule. The author has an hindex of 41, co-authored 235 publications receiving 5110 citations. Previous affiliations of Clifford George include Ben-Gurion University of the Negev & Naval Surface Warfare Center.
Papers published on a yearly basis
Papers
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TL;DR: 1,3,3-Trinitroazetidine (1) was synthesized via a Mannich condensation and its structure elucidated by X-ray crystallography as mentioned in this paper.
Abstract: 1,3,3-Trinitroazetidine (1) was synthesized via a Mannich condensation and its structure elucidated by X-ray crystallography
176 citations
168 citations
TL;DR: In the absence of acid catalysts, the glyoxal hemiacetal derivative 2,3-dihydroxy-1,4-dioxane reacts with benzylamine or 4-pyridylmethylamine in acetonitrile solvent to produce 9,10-bis(arylmethyl)9, 10-diaza- 1,4,5,8-8-tetraoxaperhydroanthracenes 13a,b.
Abstract: The condensation of glyoxal with benzylamine leads to 2,4,6,8,10,12-hexabenzyl-2,4,6,8,10,12-tetraazatetracyclo(5.5.0.0{sup 5,9}.0{sup 3,11})dodecane (2a) in solvents such as acetonitrile or methanol with formic acid catalyst. Six phenyl-substituted derivatives of 2a have been prepared and the scope of the reaction has been examined. Intermediates 1,2-bis(benzylamine)-1,2-ethanediol (6) and N,N{prime}-dibenzyl-1,2-ethanediimine (7) have been prepared and the mechanism of their conversion to 2a is discussed. In the absence of acid catalysts, the glyoxal hemiacetal derivative 2,3-dihydroxy-1,4-dioxane reacts with benzylamine or 4-pyridylmethylamine in acetonitrile solvent to produce 9,10-bis(arylmethyl)9,10-diaza-1,4,5,8-tetraoxaperhydroanthracenes 13a,b.
168 citations
TL;DR: Two conformationally rigid carbocyclic analogues of AZT are constructed which are locked permanently into opposite 2E (north) and 3E (south) conformations in order to test the ability of the corresponding 5‘-triphosphates to inhibit RT.
Abstract: It has been proposed that the preference of 3‘-azido-3‘-deoxythymidine (AZT) for the extreme 3E (south) conformation, as observed in its X-ray structure, is responsible for its potent anti-HIV acti...
161 citations
TL;DR: It was concluded that the tunneling efficiency across the molecule is the determining factor for conduction in this metal-molecule-metal system.
Abstract: To investigate the electrical characteristics of organometallic complexes as molecular conductors, organometallic π-conjugated molecules of the type trans-[PtL2(C⋮CC6H4SAc-4)2], where L = PCy3, PBu...
149 citations
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TL;DR: This tutorial review provides a sampling of renowned fluorinated drugs and their mode of action with a discussion clarifying the role and impact of fluorine substitution on drug potency.
Abstract: It has become evident that fluorinated compounds have a remarkable record in medicinal chemistry and will play a continuing role in providing lead compounds for therapeutic applications. This tutorial review provides a sampling of renowned fluorinated drugs and their mode of action with a discussion clarifying the role and impact of fluorine substitution on drug potency.
4,664 citations
TL;DR: Reaction of R,â-Unsaturated Carbonyl Compounds 3127: Reaction of R-UnSaturated Carbonies 3127 7.1.6.
Abstract: 4.2.8. Reductive Coupling 3109 5. Reaction of Aromatic Compounds 3110 5.1. Electrophilic Substitutions 3110 5.2. Radical Substitution 3111 5.3. Oxidative Coupling 3111 5.4. Photochemical Reactions 3111 6. Reaction of Carbonyl Compounds 3111 6.1. Nucleophilic Additions 3111 6.1.1. Allylation 3111 6.1.2. Propargylation 3120 6.1.3. Benzylation 3121 6.1.4. Arylation/Vinylation 3121 6.1.5. Alkynylation 3121 6.1.6. Alkylation 3121 6.1.7. Reformatsky-Type Reaction 3122 6.1.8. Direct Aldol Reaction 3122 6.1.9. Mukaiyama Aldol Reaction 3124 6.1.10. Hydrogen Cyanide Addition 3125 6.2. Pinacol Coupling 3126 6.3. Wittig Reactions 3126 7. Reaction of R,â-Unsaturated Carbonyl Compounds 3127
2,031 citations
1,562 citations
TL;DR: In this paper, a review of the physical measurements made on the α-M(dca)2 series is given, together with interpretations for the different net exchange coupling and consequent 3D order.
959 citations
TL;DR: This Review covers the major advances with the most general applicability and emphasizes new insights into the development of efficient platform methodologies for building reliable molecular electronic devices with desired functionalities through the combination of programmed bottom-up self-assembly and sophisticated top-down device fabrication.
Abstract: Creating functional electrical circuits using individual or ensemble molecules, often termed as “molecular-scale electronics”, not only meets the increasing technical demands of the miniaturization of traditional Si-based electronic devices, but also provides an ideal window of exploring the intrinsic properties of materials at the molecular level. This Review covers the major advances with the most general applicability and emphasizes new insights into the development of efficient platform methodologies for building reliable molecular electronic devices with desired functionalities through the combination of programmed bottom-up self-assembly and sophisticated top-down device fabrication. First, we summarize a number of different approaches of forming molecular-scale junctions and discuss various experimental techniques for examining these nanoscale circuits in details. We then give a full introduction of characterization techniques and theoretical simulations for molecular electronics. Third, we highlig...
949 citations