C
Clive Gentry
Researcher at Wolfson Centre for Age-Related Diseases
Publications - 59
Citations - 6789
Clive Gentry is an academic researcher from Wolfson Centre for Age-Related Diseases. The author has contributed to research in topics: Hyperalgesia & Nociception. The author has an hindex of 38, co-authored 58 publications receiving 6210 citations. Previous affiliations of Clive Gentry include University of Cambridge & King's College.
Papers
More filters
Journal ArticleDOI
Transient Receptor Potential A1 Is a Sensory Receptor for Multiple Products of Oxidative Stress
TL;DR: Electrophysiological methods and measurements of intracellular calcium concentration show that TRPA1 is activated by several classes of endogenous thiol-reactive molecules and demonstrate that multiple agents produced during episodes of oxidative stress can activate TRpa1 expressed in sensory neurons.
Journal ArticleDOI
Epilepsy, hyperalgesia, impaired memory, and loss of pre- and postsynaptic GABA(B) responses in mice lacking GABA(B(1))
Valerie Schuler,Christian Lüscher,Christophe Blanchet,Norman Klix,Gilles Sansig,Klaus Klebs,Markus Schmutz,Jakob Heid,Clive Gentry,Laszlo Urban,Alyson Fox,Will P.J.M Spooren,Anne-Lise Jaton,Jean-Marie Vigouret,Mario F. Pozza,Peter H. Kelly,Johannes Mosbacher,Wolfgang Froestl,Edgar Käslin,Reinhard Korn,Serge Bischoff,Klemens Kaupmann,Herman van der Putten,Bernhard Bettler +23 more
TL;DR: It is demonstrated that Balb/c mice lacking the GABA(B(1)) subunit are viable, exhibit spontaneous seizures, hyperalgesia, hyperlocomotor activity, and memory impairment, and casts doubt on the existence of proposed receptor subtypes.
Journal ArticleDOI
Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain
Anna K. Clark,Ping K. Yip,John Grist,Clive Gentry,Amelia A. Staniland,Fabien Marchand,Maliheh Dehvari,Glen Wotherspoon,Janet Winter,Jakir Hussain Ullah,Stuart Bevan,Marzia Malcangio +11 more
TL;DR: It is suggested that under conditions of increased nociception, microglial CatS is responsible for the liberation of neuronal FKN, which stimulates p38 MAPK phosphorylation in microglia, thereby activating neurons via the release of pronociceptive mediators.
Journal ArticleDOI
Pain related behaviour in two models of osteoarthritis in the rat knee.
Janet Fernihough,Clive Gentry,Marzia Malcangio,Alyson Fox,John Rediske,Theodore C. Pellas,Bruce L. Kidd,Stuart Bevan,Janet Winter +8 more
TL;DR: An analysis of pain related behaviours in two models of OA in the rat: partial medial meniscectomy and iodoacetate injection provides a basis for studies on the mechanisms of pain in OA, and for development of novel therapeutic analgesics.
Journal ArticleDOI
VR1 protein expression increases in undamaged DRG neurons after partial nerve injury.
TL;DR: Examination of the expression of the sensory neuron‐specific cation channel Vanilloid Receptor 1 (VR1), an important transducer of noxious stimuli, in three models of nerve injury in the rat found that VR1‐IR persisted in the transected sciatic nerve proximal to the lesion, despite its down‐regulation in the damaged neuronal somata.