C
Coleen R. Hacker
Researcher at Hoffmann-La Roche
Publications - 11
Citations - 2750
Coleen R. Hacker is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Internal medicine & Genomic library. The author has an hindex of 7, co-authored 10 publications receiving 2652 citations.
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Journal ArticleDOI
Human Genome Sequencing Using Unchained Base Reads on Self-Assembling DNA Nanoarrays
Radoje Drmanac,Andrew B. Sparks,Matthew J. Callow,Aaron L. Halpern,Norman L. Burns,Bahram G. Kermani,Paolo Carnevali,Igor Nazarenko,Geoffrey B. Nilsen,George Yeung,Fredrik A. Dahl,Andres Fernandez,Bryan Staker,Krishna Pant,Jonathan Baccash,Adam P. Borcherding,Anushka Brownley,Ryan J. Cedeno,Linsu Chen,Daniel F. Chernikoff,Alex Cheung,Razvan Chirita,Benjamin Curson,Jessica Ebert,Coleen R. Hacker,Robert Hartlage,Brian Hauser,Steve Huang,Yuan Jiang,Vitali Karpinchyk,Mark Koenig,Calvin Kong,Tom Landers,Catherine Le,Jia Liu,Celeste E. McBride,Matt Morenzoni,Robert E. Morey,Karl Mutch,Helena Perazich,Kimberly Perry,Brock A. Peters,Joe Peterson,Charit L. Pethiyagoda,Kaliprasad Pothuraju,Claudia Richter,Abraham M. Rosenbaum,Shaunak Roy,Jay Shafto,Uladzislau Sharanhovich,Karen W. Shannon,Conrad G. Sheppy,Michel Sun,Joseph V. Thakuria,Anne Tran,Dylan Vu,Alexander Wait Zaranek,Xiaodi Wu,Snezana Drmanac,Arnold R. Oliphant,William C. Banyai,Bruce L. Martin,Dennis G. Ballinger,George M. Church,Clifford Reid +64 more
TL;DR: A genome sequencing platform that achieves efficient imaging and low reagent consumption with combinatorial probe anchor ligation chemistry to independently assay each base from patterned nanoarrays of self-assembling DNA nanoballs is described.
Journal ArticleDOI
Blocks of Limited Haplotype Diversity Revealed by High-Resolution Scanning of Human Chromosome 21
Nila Patil,Anthony Berno,David A. Hinds,Wade A. Barrett,Jigna Doshi,Coleen R. Hacker,Curtis Kautzer,Danny H. Lee,Claire Marjoribanks,David P. McDonough,Bich T. N. Nguyen,Michael Norris,John B. Sheehan,Naiping Shen,David L. Stern,Renee Stokowski,Daryl J. Thomas,Mark Trulson,Kanan R. Vyas,Kelly A. Frazer,Stephen P. A. Fodor,David R. Cox +21 more
TL;DR: High-density oligonucleotide arrays are used in combination with somatic cell genetics to identify a large fraction of all common human chromosome 21 SNPs and to directly observe the haplotype structure defined by these SNPs.
Journal ArticleDOI
Empirical characterization of the expression ratio noise structure in high-density oligonucleotide arrays
TL;DR: In this paper, the authors introduce scoring functions for expression ratios, and associated quality measures, and characterize the log-ratio noise structure using robust estimates of their intensity dependent variance.
Journal ArticleDOI
In vivo transcriptional profile analysis reveals RNA splicing and chromatin remodeling as prominent processes for adult neurogenesis.
Daniel A. Lim,Mayte Suárez-Fariñas,Felix Naef,Coleen R. Hacker,Benedicte Menn,Hirohide Takebayashi,Marcelo O. Magnasco,Nila Patil,Arturo Alvarez-Buylla +8 more
TL;DR: The data greatly expand the catalogue of cell cycle components, transcription factors, and migration genes for adult SVZ neurogenesis and reveal RNA splicing and chromatin remodeling as prominent biological processes for these germinal cells.
Journal ArticleDOI
Prenatal Screening for 22q11.2 Deletion Using a Targeted Microarray-Based Cell-Free DNA Test
Maximilian Schmid,Eric Wang,P. Bogard,Elisa Bevilacqua,Coleen R. Hacker,Susie Wang,Jigna Doshi,Karen White,Jennifer A. Kaplan,Andrew B. Sparks,Jacques Jani,Renee Stokowski +11 more
TL;DR: In this article, a targeted microarray-based cell-free DNA (cfDNA) test (Harmony Prenatal Test®) was used for the identification of pregnancies at increased risk for 22q11.2 deletion.