C
Colin B. Reese
Researcher at University of Cambridge
Publications - 183
Citations - 10216
Colin B. Reese is an academic researcher from University of Cambridge. The author has contributed to research in topics: Ribonucleoside & Protecting group. The author has an hindex of 37, co-authored 183 publications receiving 9933 citations. Previous affiliations of Colin B. Reese include King's College.
Papers
More filters
Journal ArticleDOI
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα
Dario R. Alessi,Stephen R. James,C. Peter Downes,Andrew B. Holmes,Piers R. J. Gaffney,Colin B. Reese,Philip Cohen +6 more
TL;DR: In this paper, a protein kinase that phosphorylates PKB α at Thr308 and increases its activity over 30-fold was found to play a key role in mediating the activation of PKB by insulin and growth factors.
Journal ArticleDOI
Dual Role of Phosphatidylinositol-3,4,5-trisphosphate in the Activation of Protein Kinase B
David Stokoe,L. Stephens,Terry D. Copeland,Piers R. J. Gaffney,Colin B. Reese,Gavin F. Painter,Andrew B. Holmes,Frank McCormick,Phillip T. Hawkins +8 more
TL;DR: Chromatographic separation of brain cytosol revealed a kinase activity that phosphorylated and activated PKB only in the presence of phosphatidylinositol-3, 4,5-trisphosphate [PtdIns(3,4,5)P3].
Journal ArticleDOI
Protein Kinase B Kinases That Mediate Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Activation of Protein Kinase B
Len R. Stephens,Karen E. Anderson,David Stokoe,Hediye Erdjument-Bromage,Gavin F. Painter,Andrew B. Holmes,Piers R. J. Gaffney,Colin B. Reese,Frank McCormick,Paul Tempst,John Coadwell,Phillip T. Hawkins +11 more
TL;DR: Four isoforms of these PKB kinases were purified from sheep brain and their heterologous expression augments receptor activation of PKB, which suggests they are the primary signal transducers that enable PtdIns(3,4,5)P3 or PTDIns- (3, 4)P2 to activate PKB and hence to control signaling pathways regulating cell survival, glucose uptake, and glycogen metabolism.
Journal ArticleDOI
3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase.
Dario R. Alessi,Maria Deak,Antonio Casamayor,F. Barry Caudwell,Nick Morrice,David Norman,Piers R. J. Gaffney,Colin B. Reese,Colin N. MacDougall,Diane Harbison,Alan Ashworth,Mary Bownes +11 more
TL;DR: Human PDK1 is homologous to the Drosophila protein kinase DSTPK61, which has been implicated in the regulation of sex differentiation, oogenesis and spermatogenesis and is likely to mediate the activation of PKB by insulin or growth factors.