Colin Luo

TL;DR: Enzyme-responsive peptide-polymer amphiphiles are assembled as spherical micellar nanoparticles, and undergo a morphological transition from spherical-shaped, discrete materials to network-like assemblies when acted upon by matrix metalloproteinases.

TL;DR: Results indicate that the myocardial matrix alters several key pathways after MI creating a pro-regenerative environment, further demonstrating its promise as a potential post-MI therapy.

TL;DR: An example of "coevolution" between a DNA-binding transcription factor and its cis-regulatory site, reminiscent of the coevolution of protein binding partners, is demonstrated, that allows for conserved transcriptional regulation despite continued genetic change.

TL;DR: Cyclic peptides with low viscosity for catheter delivery are reported on, which form self-assembled peptide hydrogels following enzymatic cleavage and demonstrated delivery in vivo.

TL;DR: This analysis reveals that YAP regulatory specificity is achieved by at least three mechanisms: divergence of DNA-binding sequences into two subfamilies; condition-specific combinatorial regulation by multiple Yap factors; and interactions of Yap 1, 4, and 6 with chromatin remodeling proteins.