Colinda L.G.J. Scheele

TL;DR: Novel therapy strategies based on cell‐cycle modulation, modifications of existing drugs, or enhanced drug‐delivery vehicles may be used to specifically target this subpopulation of tumor cells, and thereby have the potential to prevent disease recurrence.

TL;DR: A complementary approach is proposed that mathematically describes “stemness” as an emergent property arising from a stochastic competition for space, and predicts from that competition the robust emergence of a region made of functional stem cells, as well as give simple predictions on lineage-survival probability.

TL;DR: Zhang et al. as mentioned in this paper applied genome-wide ChIP profiling of YAP to systematically identify enhancers that are bound by YAP/TEAD4 and found that activating YAP associates with enhancer loci via TEAD4-DNA-binding protein and stimulates cancer aggressiveness.

TL;DR: A theory of stem cell dynamics as a stochastic competition for access to a spatially-localized niche, giving rise to a “stochastic conveyor-belt” model that predicts a common (“universal”) functional dependence of the long-term clonal survival probability on the position within the niche, as well as the emergence of a well-defined number of “functional” stem cells.

TL;DR: In this article, a combination of intravital microscopy and genetic reporter systems was used to quantify the dynamics of mammary gland growth and remodeling from single-cell level to organ scale.