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Conny Gysemans
Researcher at Katholieke Universiteit Leuven
Publications - 150
Citations - 13211
Conny Gysemans is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: NOD mice & Immune system. The author has an hindex of 51, co-authored 142 publications receiving 11334 citations. Previous affiliations of Conny Gysemans include Catholic University of Leuven.
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Vitamin D: modulator of the immune system.
TL;DR: 1,25(OH)(2)D(3) is described as an immunomodulator targeting various immune cells, including monocytes, macrophages, dendritic cells (DCs), as well as T-lymphocytes and B-LYmphocytes, hence modulating both innate and adaptive immune responses.
Journal Article
Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T-CELL suppressive activity
Kiavash Movahedi,Martin Guiliams,Jan Van den Bossche,Rafael Van den Bergh,Conny Gysemans,Alain Beschin,Patrick De Baetselier,Jo A. Van Ginderachter +7 more
TL;DR: This work identified 2 distinct MDSC subfractions with clear morphologic, molecular, and functional differences, and refined tumor-induced MDSCs functions by uncovering mechanistically distinct M DSC subpopulations, potentially relevant for MDSc-targeted therapies.
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Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell–suppressive activity
Kiavash Movahedi,Martin Guilliams,Jan Van den Bossche,Rafael Van den Bergh,Conny Gysemans,Alain Beschin,Patrick De Baetselier,Jo A. Van Ginderachter +7 more
TL;DR: In this article, the authors identified two distinct MDSC subfractions with clear morphologic, molecular, and functional differences, i.e., low-density polymorphonuclear cells (PMN-MDSCs) and high-density neutrophils.
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Different Tumor Microenvironments Contain Functionally Distinct Subsets of Macrophages Derived from Ly6C(high) Monocytes
Kiavash Movahedi,Damya Laoui,Conny Gysemans,Martijn Baeten,Geert Stangé,Jan Van den Bossche,Matthias Mack,Daniel Pipeleers,Peter In't Veld,Patrick De Baetselier,Jo A. Van Ginderachter +10 more
TL;DR: The data help to unravel the complexities of the tumor-infiltrating myeloid cell compartment and provide a rationale for targeting specialized TAM subsets, thereby optimally "re-educating" the TAM compartment.
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Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates
Lajos Mátés,Marinee Chuah,Eyayu Belay,Boris Jerchow,Namitha Manoj,Abel Acosta-Sanchez,Dawid P. Grzela,Andrea Schmitt,Katja Becker,Janka Matrai,L. Ma,Ermira Samara-Kuko,Conny Gysemans,Diana Pryputniewicz,Csaba Miskey,Bradley S. Fletcher,Thierry VandenDriessche,Zoltán Ivics,Zsuzsanna Izsvák,Zsuzsanna Izsvák +19 more
TL;DR: The newly developed transposase yields unprecedented stable gene transfer efficiencies following nonviral gene delivery that compare favorably to stable transduction efficiencies with integrating viral vectors and is expected to facilitate widespread applications in functional genomics and gene therapy.