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Constance Alabert
Researcher at University of Copenhagen
Publications - 23
Citations - 2979
Constance Alabert is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Chromatin & DNA replication. The author has an hindex of 15, co-authored 19 publications receiving 2573 citations. Previous affiliations of Constance Alabert include University of Dundee & University of Copenhagen Faculty of Health Sciences.
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Journal ArticleDOI
Chromatin Replication and Epigenome Maintenance
Constance Alabert,Anja Groth +1 more
TL;DR: In this paper, the authors discuss the importance of chromatin structure and organization in eukaryotic genomes and their importance in maintaining the integrity of both genome and epigenome integrity with severe consequences for the organism.
Journal ArticleDOI
Chromatin replication and epigenome maintenance
Constance Alabert,Anja Groth +1 more
TL;DR: Stability and function of eukaryotic genomes are closely linked to chromatin structure and organization, and if DNA synthesis is perturbed, cells can suffer loss of both genome and epigenome integrity with severe consequences for the organism.
Journal ArticleDOI
Two distinct modes for propagation of histone PTMs across the cell cycle
Constance Alabert,Teresa K. Barth,Nazaret Reverón-Gómez,Simone Sidoli,Andreas Schmidt,Ole N. Jensen,Ole N. Jensen,Axel Imhof,Anja Groth +8 more
TL;DR: It is shown that post-translational modifications (PTMs) are transmitted with parental histones to newly replicated DNA and that chromatin states oscillate within the cell cycle.
Journal ArticleDOI
Nascent chromatin capture proteomics determines chromatin dynamics during DNA replication and identifies unknown fork components
Constance Alabert,Jimi-Carlo Bukowski-Wills,Sung Bau Lee,Georg Kustatscher,Kyosuke Nakamura,Flavia de Lima Alves,Patrice Menard,Jakob Mejlvang,Juri Rappsilber,Juri Rappsilber,Anja Groth +10 more
TL;DR: This work uses nascent chromatin capture (NCC) to profile chromatin proteome dynamics during replication in human cells, and identifies FAM111A as a replication factor required for PCNA loading, providing an extensive resource to understand genome and epigenome maintenance.
Journal ArticleDOI
Mrc1 and Tof1 promote replication fork progression and recovery independently of Rad53.
Hélène Tourrière,Gwennaelle Versini,Violeta Cordon-Preciado,Constance Alabert,Philippe Pasero +4 more
TL;DR: It is shown that stalled forks did not collapse in mrc1Delta cells exposed to hydroxyurea (HU) as they do in rad53 mutants, and the critical role of Mrc1p in HU is to promote fork recovery in a Rad53p-independent manner, presumably through the formation of a stable fork-pausing complex.