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Corentin Claeys Bouuaert
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 24
Citations - 573
Corentin Claeys Bouuaert is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Transposable element & Transposase. The author has an hindex of 12, co-authored 23 publications receiving 420 citations. Previous affiliations of Corentin Claeys Bouuaert include Université catholique de Louvain & University of Nottingham.
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Journal ArticleDOI
Mariner and the ITm Superfamily of Transposons.
TL;DR: The molecular mechanism of ITm transposition and its regulation is reviewed, focusing mostly on the mariner elements, which are understood in the greatest detail owing to in vitro reconstitution and structural analysis.
Journal ArticleDOI
rahu is a mutant allele of Dnmt3c, encoding a DNA methyltransferase homolog required for meiosis and transposon repression in the mouse male germline.
Devanshi Jain,Cem Meydan,Julian Lange,Corentin Claeys Bouuaert,Nathalie Lailler,Christopher E. Mason,Kathryn V. Anderson,Scott Keeney +7 more
TL;DR: Dnmt3crahu mutant males fail to establish normal methylation within LINE and LTR retrotransposon sequences in the germline and accumulate higher levels of transposon-derived transcripts and proteins, particularly from distinct L1 and ERVK retrotransposing families.
Journal ArticleDOI
The autoregulation of a eukaryotic DNA transposon
Corentin Claeys Bouuaert,Karen Lipkow,Karen Lipkow,Steven S. Andrews,Danxu Liu,Ronald Chalmers +5 more
TL;DR: It is shown that autoregulation of Hsmar1 operates during assembly of the transpososome and arises from the multimeric state of thetransposase, mediated by a competition for binding sites, which may therefore be widely applicable.
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Transposition of the human Hsmar1 transposon: rate-limiting steps and the importance of the flanking TA dinucleotide in second strand cleavage
TL;DR: It is proposed that mariner excision involves a significant conformational change between first- and second-strand cleavage at each transposon end, which requires specific contacts between transposase and the flanking TA dinucleotide.
Journal ArticleDOI
DNA-driven condensation assembles the meiotic DNA break machinery.
Corentin Claeys Bouuaert,Corentin Claeys Bouuaert,Stephen Pu,Juncheng Wang,Cédric A. Oger,Dima Daccache,Wei Xie,Dinshaw J. Patel,Scott Keeney +8 more
TL;DR: In this paper, the authors studied how the DSB machinery self-assembles on chromosome axes to create centres of DSB activity and proposed that multilayered control of Spo11 arises from the recruitment of regulatory components and modulation of the biophysical properties of the condensates.