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Corey E. Bakalarski
Researcher at Genentech
Publications - 30
Citations - 9900
Corey E. Bakalarski is an academic researcher from Genentech. The author has contributed to research in topics: DNA damage & Mass spectrometry. The author has an hindex of 22, co-authored 27 publications receiving 8961 citations. Previous affiliations of Corey E. Bakalarski include Boston Children's Hospital & Harvard University.
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Journal ArticleDOI
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
Shuhei Matsuoka,Bryan A. Ballif,Agata Smogorzewska,Agata Smogorzewska,E. Robert McDonald,Kristen E. Hurov,Ji Luo,Corey E. Bakalarski,Zhenming Zhao,Nicole L. Solimini,Yaniv Lerenthal,Yosef Shiloh,Steven P. Gygi,Stephen J. Elledge +13 more
TL;DR: A large-scale proteomic analysis of proteins phosphorylated in response to DNA damage on consensus sites recognized by ATM and ATR is performed and more than 900 regulated phosphorylation sites encompassing over 700 proteins are identified.
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Global Survey of Phosphotyrosine Signaling Identifies Oncogenic Kinases in Lung Cancer
Klarisa Rikova,Ailan Guo,Qingfu Zeng,Anthony Possemato,Jian Yu,Herbert Haack,Julie Nardone,Kimberly Lee,Cynthia Reeves,Yu Li,Yerong Hu,Zhi-Ping Tan,Matthew P. Stokes,Laura Sullivan,Jeffrey Mitchell,Randy Wetzel,Joan MacNeill,Jian Min Ren,Jin Yuan,Corey E. Bakalarski,Judit Villén,Jon M. Kornhauser,Bradley L. Smith,Daiqiang Li,Xinmin Zhou,Steven P. Gygi,Ting-Lei Gu,Roberto D. Polakiewicz,John Rush,Michael J. Comb +29 more
TL;DR: By focusing on activated cell circuitry, the approach outlined here provides insight into cancer biology not available at the chromosomal and transcriptional levels and can be applied broadly across all human cancers.
Journal ArticleDOI
A quantitative atlas of mitotic phosphorylation.
Noah Dephoure,Chunshui Zhou,Judit Villén,Sean A. Beausoleil,Corey E. Bakalarski,Stephen J. Elledge,Steven P. Gygi +6 more
TL;DR: Analysis of non-proline site-containing phosphopeptides identified two unique motifs that suggest there are at least two undiscovered mitotic kinases, suggesting that many of the proteins identified may be CDK substrates.
Journal ArticleDOI
The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy
Baris Bingol,Joy S. Tea,Lilian Phu,Mike Reichelt,Corey E. Bakalarski,Qinghua Song,Oded Foreman,Donald S. Kirkpatrick,Morgan Sheng +8 more
TL;DR: In this paper, Parkin ubiquitinates and tags damaged mitochondria for clearance, and USP30, a deubiquitinase localized to mitochondria, antagonizes mitophagy driven by the ubiquitin ligase parkin.
Journal ArticleDOI
Loss of the Tumor Suppressor BAP1 Causes Myeloid Transformation
Anwesha Dey,Dhaya Seshasayee,Rajkumar Noubade,Dorothy French,Jinfeng Liu,Mira S. Chaurushiya,Donald S. Kirkpatrick,Victoria Pham,Jennie R. Lill,Corey E. Bakalarski,Jiansheng Wu,Lilian Phu,Paula Katavolos,Lindsay M. LaFave,Omar Abdel-Wahab,Zora Modrusan,Somasekar Seshagiri,Ken C. Dong,Zhonghua Lin,Mercedesz Balazs,Rowena Suriben,Kim Newton,Sarah G. Hymowitz,Guillermo Garcia-Manero,Flavius Martin,Ross L. Levine,Vishva M. Dixit +26 more
TL;DR: It is shown that mouse Bap1 gene deletion is lethal during embryogenesis, but systemic or hematopoietic-restricted deletion in adults recapitulates features of human myelodysplastic syndrome (MDS), and Knockin mice expressing B AP1 with a 3xFlag tag revealed that BAP1 interacts with host cell factor–1, O-linked N-acetylglucosamine transferase (OGT), and the polycomb group proteins ASXL