Author
Courtney D. Thornburg
Other affiliations: Boston Children's Hospital, Duke University, Durham University ...read more
Bio: Courtney D. Thornburg is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Medicine & Anemia. The author has an hindex of 29, co-authored 118 publications receiving 3011 citations. Previous affiliations of Courtney D. Thornburg include Boston Children's Hospital & Duke University.
Topics: Medicine, Anemia, Sickle cell anemia, Acute chest syndrome, Population
Papers published on a yearly basis
Papers
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SUNY Downstate Medical Center1, University of Mississippi2, Johns Hopkins University3, Children's National Medical Center4, Howard University5, Duke University6, University of Texas at Dallas7, Medical University of South Carolina8, University of Miami9, Emory University10, Boston Children's Hospital11, University of Alabama at Birmingham12, Georgia Regents University13, National Institutes of Health14
TL;DR: Hydroxycarbamide can now be considered for all very young children with sickle-cell anaemia, with some evidence for decreased acute chest syndrome, hospitalisation rates, and transfusion.
606 citations
TL;DR: Sickle cell erythrocytes exhibit cell-intrinsic resistance to malaria in part through an atypical miRNA activity, which may represent a unique host defense strategy against complex eukaryotic pathogens.
266 citations
Duke University1, Emory University2, SUNY Downstate Medical Center3, Children's Mercy Hospital4, University of Mississippi Medical Center5, Johns Hopkins University School of Medicine6, University of Alabama at Birmingham7, University of Miami8, Baylor College of Medicine9, St. Jude Children's Research Hospital10
TL;DR: Despite expected mild myelosuppression, hydroxyurea was not associated with an increased risk of bacteremia or serious infection, and was associated with statistically significantly lower rates of initial and recurrent episodes of pain, dactylitis, acute chest syndrome, and hospitalization.
205 citations
Medical University of Vienna1, Bayer2, University of Cincinnati Academic Health Center3, Cincinnati Children's Hospital Medical Center4, Nationwide Children's Hospital5, Kazan State Medical University6, Riley Hospital for Children7, Paris Descartes University8, Boston Children's Hospital9, University Medical Center Groningen10, McMaster Children's Hospital11, Sheba Medical Center12, Charité13, University of Montpellier14, University of Padua15, Northwestern University16, Baylor College of Medicine17, Ural Federal University18, King's College London19, Newcastle upon Tyne Hospitals NHS Foundation Trust20, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico21, Nemours Foundation22, University of Alberta23, Children's Hospital Los Angeles24, McMaster University25, Maastricht University Medical Centre26, Royal Children's Hospital27, Katholieke Universiteit Leuven28
TL;DR: Treatment with rivaroxaban resulted in a similarly low recurrence risk and reduced thrombotic burden without increased bleeding, as compared with standard anticoagulants in children with acute venous thromboembolism.
155 citations
TL;DR: Monitoring of adherence to hydroxyurea therapy in children with sickle cell anemia and the Modified Morisky Scale may be used to identify children at high risk for poor response because of non-adherence and children with good adherence with poor response Because of individual pharmacodynamics.
129 citations
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TL;DR: It is suggested that if assessment of overdoses were left to house doctors there would be an increase in admissions to psychiatric units, outpatients, and referrals to social services, but for house doctors to assess overdoses would provide no economy for the psychiatric or social services.
Abstract: admission. This proportion could already be greater in some parts of the country and may increase if referrals of cases of self-poisoning increase faster than the facilities for their assessment and management. The provision of social work and psychiatric expertise in casualty departments may be one means of preventing unnecessary medical admissions without risk to the patients. Dr Blake's and Dr Bramble's figures do not demonstrate, however, that any advantage would attach to medical teams taking over assessment from psychiatrists except that, by implication, assessments would be completed sooner by staff working on the ward full time. What the figures actually suggest is that if assessment of overdoses were left to house doctors there would be an increase in admissions to psychiatric units (by 19°U), outpatients (by 5O°'), and referrals to social services (by 140o). So for house doctors to assess overdoses would provide no economy for the psychiatric or social services. The study does not tell us what the consequences would have been for the six patients who the psychiatrists would have admitted but to whom the house doctors would have offered outpatient appointments. E J SALTER
4,497 citations
Queen Mary University of London1, National Health Service2, University of Toronto3, Manchester Royal Infirmary4, NewYork–Presbyterian Hospital5, University of New South Wales6, Hospital of the University of Pennsylvania7, University of Washington8, Boston Children's Hospital9, Hull York Medical School10, King's College London11, St James's University Hospital12, Scripps Research Institute13, Harvard University14
TL;DR: This consensus document aims to report on new data and provide consensus-based recommendations relating to diagnosis and treatment of ITP in adults, in children, and during pregnancy.
1,902 citations
University of Rochester1, University of Texas Southwestern Medical Center2, University of North Carolina at Chapel Hill3, Thomas Jefferson University4, University of Colorado Denver5, University of Virginia6, University of Miami7, Johns Hopkins University8, University of Florida9, Harvard University10, Duke University11, Cincinnati Children's Hospital Medical Center12, Mayo Clinic13, National Institutes of Health14, Food and Drug Administration15, American Institutes for Research16
TL;DR: Hydxyurea and transfusion therapy are strongly recommended for many individuals with SCD and many other recommendations are based on quality of evidence that is less than high due to the paucity of clinical trials regarding screening, management, and monitoring for individuals withSCD.
Abstract: Importance Sickle cell disease (SCD) is a life-threatening genetic disorder affecting nearly 100 000 individuals in the United States and is associated with many acute and chronic complications requiring immediate medical attention. Two disease-modifying therapies, hydroxyurea and long-term blood transfusions, are available but underused. Objective To support and expand the number of health professionals able and willing to provide care for persons with SCD. Evidence Review Databases of MEDLINE (including in-process and other nonindexed citations), EMBASE, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, CINAHL, TOXLINE, and Scopus were searched using prespecified search terms and keywords to identify randomized clinical trials, nonrandomized intervention studies, and observational studies. Literature searches of English-language publications from 1980 with updates through April 1, 2014, addressed key questions developed by the expert panel members and methodologists. Findings Strong recommendations for preventive services include daily oral prophylactic penicillin up to the age of 5 years, annual transcranial Doppler examinations from the ages of 2 to 16 years in those with sickle cell anemia, and long-term transfusion therapy to prevent stroke in those children with abnormal transcranial Doppler velocity (≥200 cm/s). Strong recommendations addressing acute complications include rapid initiation of opioids for treatment of severe pain associated with a vasoocclusive crisis, and use of incentive spirometry in patients hospitalized for a vasoocclusive crisis. Strong recommendations for chronic complications include use of analgesics and physical therapy for treatment of avascular necrosis, and use of angiotensin-converting enzyme inhibitor therapy for microalbuminuria in adults with SCD. Strong recommendations for children and adults with proliferative sickle cell retinopathy include referral to expert specialists for consideration of laser photocoagulation and for echocardiography to evaluate signs of pulmonary hypertension. Hydroxyurea therapy is strongly recommended for adults with 3 or more severe vasoocclusive crises during any 12-month period, with SCD pain or chronic anemia interfering with daily activities, or with severe or recurrent episodes of acute chest syndrome. A recommendation of moderate strength suggests offering treatment with hydroxyurea without regard to the presence of symptoms for infants, children, and adolescents. In persons with sickle cell anemia, preoperative transfusion therapy to increase hemoglobin levels to 10 g/dL is strongly recommended with a moderate strength recommendation to maintain sickle hemoglobin levels of less than 30% prior to the next transfusion during long-term transfusion therapy. A strong recommendation to assess iron overload is accompanied by a moderate strength recommendation to begin iron chelation therapy when indicated. Conclusions and Relevance Hydroxyurea and transfusion therapy are strongly recommended for many individuals with SCD. Many other recommendations are based on quality of evidence that is less than high due to the paucity of clinical trials regarding screening, management, and monitoring for individuals with SCD.
1,156 citations