Courtney Hyland

TL;DR: It is proposed that MET amplification may promote drug resistance in other ERBB-driven cancers as well after it was found that amplification of MET causes gefitinib resistance by driving ERBB3 (HER3)–dependent activation of PI3K, a pathway thought to be specific to EGFR/ERBB family receptors.

TL;DR: Functional categories of genes that have likely evolved under purifying or positive selection for copy number changes may have been fixed by positive selection and involved in the adaptive phenotypic differentiation of humans and chimpanzees.

TL;DR: The extent of genetic variation in human populations and its impact on human health is identified and CNVs are genomic gains and losses of 1 kb or larger, differentiating it from other forms of polymorphism and/or repeated DNAs in the human genome.

TL;DR: Zong et al. as discussed by the authors present and future managers at global multinationals who have responsibility for R&D strategy to understand some of the complexities of the Chinese intellectual property environment so that they can build effective participation strategies for their organizations Understanding the misaligned incentives that result in the production of junk patents and the challenges of patent enforcement, as well as the direction of change are vital.