Cristina López-Vicario

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: Novel mechanisms underlying ω-3-polyunsaturated fatty acid actions on adipose tissue, adipocytes, and stromal vascular cells (SVC) are reported and resolvin D1 and its precursor DHA confer anti-inflammatory and proresolving actions in inflamed adiposes tissue.

TL;DR: Findings establish PPARγ expression in hepatocytes as a prosteatotic factor in fatty liver disease as determined by hepatocyte‐ and macrophage‐specific conditional knockouts.

TL;DR: Findings identify omega-3 epoxides as important regulators of inflammation and autophagy in insulin-sensitive tissues and postulate sEH as a druggable target in metabolic diseases.

TL;DR: Investigating gene expression profiling of liver biopsies from NASH patients with translational studies in mouse models of steatohepatitis and pharmacological interventions in isolated hepatocytes to identify new molecular targets in NASH indicates that impaired hepatic fatty acid desaturation and unbalanced ω-6 to ψ-3 ratio play a role in the pathogenesis of NASH.