Cristina R. Antonescu

TL;DR: It is demonstrated that cancer cells containing amplifications surrounding the MCL1 and BCL2L1 anti-apoptotic genes depend on the expression of these genes for survival, and a large majority of SCNAs identified in individual cancer types are present in several cancer types.

TL;DR: The ability of the trained ANN models to recognize SRBCTs is demonstrated, and the potential applications of these methods for tumor diagnosis and the identification of candidate targets for therapy are demonstrated.

TL;DR: Adjuvant imatinib therapy is safe and seems to improve recurrence-free survival compared with placebo after the resection of primary gastrointestinal stromal tumour.

TL;DR: The standard of care for managing patients with gastrointestinal stromal tumors (GISTs) rapidly changed after the introduction of effective molecularly targeted therapies involving tyrosine kinase inhibitors (TKIs), such as imatinib mesylate and sunitinib malate.

TL;DR: A sustained partial response to the ALK inhibitor crizotinib (PF-02341066, Pfizer) is reported in a patient with ALK-translocated IMT, as compared with no observed activity in another patient without theALK translocation, which support the dependence of ALk-rearranged tumors on AlK-mediated signaling and suggest a therapeutic strategy for genomically identified patients with the aggressive form of this soft-tissue tumor.