C
Cristina Villellas
Researcher at University of Zaragoza
Publications - 3
Citations - 267
Cristina Villellas is an academic researcher from University of Zaragoza. The author has contributed to research in topics: Efflux & Gene. The author has an hindex of 3, co-authored 3 publications receiving 243 citations.
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Journal ArticleDOI
Spectinamides: a new class of semisynthetic antituberculosis agents that overcome native drug efflux
Richard E. Lee,Julian G. Hurdle,Jiuyu Liu,David F. Bruhn,Tanja Matt,Michael S. Scherman,Pavan K. Vaddady,Zhong Zheng,Jianjun Qi,Rashid Akbergenov,Sourav Das,Dora B. Madhura,Chetan Rathi,Ashit Trivedi,Cristina Villellas,Robin B. Lee,Rakesh,Samanthi L. Waidyarachchi,Dianqing Sun,Michael R. McNeil,José A. Aínsa,Helena I. Boshoff,Mercedes Gonzalez-Juarrero,Bernd Meibohm,Erik C. Böttger,Anne J. Lenaerts +25 more
TL;DR: The antitubercular efficacy of spectinamides demonstrates that synthetic modifications to classical antibiotics can overcome the challenge of intrinsic efflux pump-mediated resistance and expands opportunities for target-based tuberculosis drug discovery.
Journal ArticleDOI
Role of the Mmr Efflux Pump in Drug Resistance in Mycobacterium tuberculosis
TL;DR: In this article, the role of the efflux pump Mmr in the development of resistance to isoniazid and other drugs in Mycobacterium tuberculosis has been investigated and it has been shown that Mmr is mainly involved in the susceptibility to quaternary compounds such as ethidium bromide and disinfectants such as CTAB.
Journal ArticleDOI
Analysis of Mutations in Streptomycin-Resistant Strains Reveals a Simple and Reliable Genetic Marker for Identification of the Mycobacterium tuberculosis Beijing Genotype
Cristina Villellas,Liselotte Aristimuño,Liselotte Aristimuño,María-Asunción Vitoria,Cristina Prat,Silvia Blanco,Darío García de Viedma,José Domínguez,Sofía Samper,José A. Aínsa +9 more
TL;DR: Tap580 is a novel polymorphism specific to the highly transmissible Beijing family of M. tuberculosis, which allows for fast detection of these strains even at the very early stages of infection.