D
D. Bicho
Researcher at University of Minho
Publications - 15
Citations - 281
D. Bicho is an academic researcher from University of Minho. The author has contributed to research in topics: DNA vaccination & Plasmid. The author has an hindex of 9, co-authored 15 publications receiving 198 citations. Previous affiliations of D. Bicho include Royal National Orthopaedic Hospital & University of Porto.
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Journal ArticleDOI
Protein transport into peroxisomes: Knowns and unknowns.
Tânia Francisco,Tony A. Rodrigues,Tony A. Rodrigues,Ana F. Dias,Ana F. Dias,Aurora Barros-Barbosa,Aurora Barros-Barbosa,D. Bicho,D. Bicho,Jorge E. Azevedo,Jorge E. Azevedo +10 more
TL;DR: The main data behind the peroxisomal matrix proteins model are reviewed, showing that insertion of cargo‐loaded receptor into the “barrel” is an ATP‐independent process, whereas extraction of the receptor back into the cytosol requires its monoubiquitination and the action of ATP‐dependent mechanoenzymes.
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Performance of a non-grafted monolithic support for purification of supercoiled plasmid DNA.
TL;DR: The binding capacity has been found to be significantly higher for sc plasmid, probably because of its compact structure, being also improved when using feedstock with increased plasmids concentrations and decreased linear velocity.
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Peroxisomal monoubiquitinated PEX5 interacts with the AAA ATPases PEX1 and PEX6 and is unfolded during its dislocation into the cytosol
Ana G. Pedrosa,Ana G. Pedrosa,Tânia Francisco,Tânia Francisco,D. Bicho,D. Bicho,Ana F. Dias,Ana F. Dias,Aurora Barros-Barbosa,Aurora Barros-Barbosa,Vera Hagmann,Gabriele Dodt,Tony A. Rodrigues,Tony A. Rodrigues,Jorge E. Azevedo,Jorge E. Azevedo +15 more
TL;DR: Evidence is provided suggesting that DTM-embedded Ub-PEX5 interacts directly with both PEX1 and PEX6 through its ubiquitin moiety and that the PEX5 polypeptide chain is globally unfolded during the ATP-dependent extraction event.
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Kefiran cryogels as potential scaffolds for drug delivery and tissue engineering applications
TL;DR: This research suggests that Kefiran cryogel could be a potential candidate for drug delivery of controlled bioactive molecules and tissue engineering scaffolding.
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Peptide-biofunctionalization of biomaterials for osteochondral tissue regeneration in early stage osteoarthritis: challenges and opportunities
TL;DR: A tissue engineering strategy comprising the use of biomaterials can provide support for neo-tissue osteochondral repair/regeneration whilst conferring proper mechanical and functional features as well as protecting biomolecular agents from premature degradation.